Total Synthesis of (±)-Sceptrin
Author(s)Nguyen, Long V.; Jamison, Timothy F
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A four-step synthesis of the dimeric pyrrole-imidazole alkaloid sceptrin is reported. The brevity of the route is based on a simple solution developed for selective assembly of the cyclobutane core of the natural product. The photochemical intermolecular [2 + 2] dimerization of a useful hymenidin surrogate enables direct entry to this enigmatic class of biologically active marine secondary metabolites. ©2020 American Chemical Society.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Nguyen, Long V. and Timothy F. Jamison, "Total Synthesis of (±)-Sceptrin." Organic Letters 22, 17 (September 2020): 6698–6702 doi. 10.1021/acs.orglett.0c01381 ©2020 Authors
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