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dc.contributor.authorBreen, Christopher P.
dc.contributor.authorParrish, Christine
dc.contributor.authorShangguan, Ning
dc.contributor.authorMajumdar, Sudip
dc.contributor.authorMurnen, Hannah
dc.contributor.authorJamison, Timothy F
dc.contributor.authorBio, Matthew M.
dc.date.accessioned2020-10-15T21:13:32Z
dc.date.available2020-10-15T21:13:32Z
dc.date.issued2020-04
dc.identifier.issn1083-6160
dc.identifier.issn1520-586X
dc.identifier.urihttps://hdl.handle.net/1721.1/128012
dc.description.abstractThe translation of olefin metathesis reactions from the laboratory to process scale has been challenging with traditional batch techniques. In this contribution, we describe a continuous membrane reactor design that selectively permeates the ethylene byproduct from metathetical processes, thereby overcoming the mass-transport limitations that have negatively influenced the efficiency of this transformation in batch vessels. The membrane sheet-in-frame pervaporation module yielded turnover numbers of >7500 in the case of diethyl diallylmalonate ring-closing metathesis. The preparation of more challenging, low-effective-molarity substrates, a cyclooctene and a 14-membered macrocyclic lactone, was also effective. A comparison of optimal membrane reactor conditions to a sealed tubular reactor revealed that the benefits of ethylene removal are most apparent at low reaction concentrations.en_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acs.oprd.0c00061en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Jamisonen_US
dc.titleA Scalable Membrane Pervaporation Approach for Continuous Flow Olefin Metathesisen_US
dc.typeArticleen_US
dc.identifier.citationBreen, Christopher P. et al. "A Scalable Membrane Pervaporation Approach for Continuous Flow Olefin Metathesis." Organic Process Research and Development (April 2020): dx.doi.org/10.1021/acs.oprd.0c00061. © 2020 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.relation.journalOrganic Process Research and Developmenten_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2020-10-01T14:33:50Z
mit.licenseOPEN_ACCESS_POLICY


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