Optical Pooled Screens in Human Cells

Author(s)
Feldman, David; Singh, Avtar; Schmid-Burgk, Jonathan; Carlson, Rebecca J.; Mezger, Anja; ... Show more
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Abstract
A screening approach that combines high-content imaging with in situ sequencing can identify genes that affect spatially and temporally defined phenotypes like morphology and subcellular localization, expanding the list of scientific questions that can be asked with genetic tools.
Date issued
2019-10
URI
https://hdl.handle.net/1721.1/128137
Department
Massachusetts Institute of Technology. Department of Physics; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; McGovern Institute for Brain Research at MIT; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Broad Institute of MIT and Harvard; Koch Institute for Integrative Cancer Research at MIT
Journal
Cell
Publisher
Elsevier BV
Citation
Feldman, David et al. "Optical Pooled Screens in Human Cells." Cell 179, 3 (October 2019): P787-799.e17 © 2019 Elsevier
Version: Author's final manuscript
ISSN
0092-8674
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