Optical Pooled Screens in Human Cells
Author(s)Feldman, David; Singh, Avtar; Schmid-Burgk, Jonathan; Carlson, Rebecca J.; Mezger, Anja; Garrity, Anthony J.; Zhang, Feng; Blainey, Paul C; ... Show more Show less
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A screening approach that combines high-content imaging with in situ sequencing can identify genes that affect spatially and temporally defined phenotypes like morphology and subcellular localization, expanding the list of scientific questions that can be asked with genetic tools.
DepartmentMassachusetts Institute of Technology. Department of Physics; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; McGovern Institute for Brain Research at MIT; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; David H. Koch Institute for Integrative Cancer Research at MIT; Broad Institute of MIT and Harvard
Feldman, David et al. "Optical Pooled Screens in Human Cells." Cell 179, 3 (October 2019): P787-799.e17 © 2019 Elsevier
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