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dc.contributor.authorAggarwal, Neerja
dc.contributor.authorCavuto, Matthew L.
dc.contributor.authorLi, Melissa
dc.contributor.authorRodman, Nathaniel H.
dc.contributor.authorSlocum, Alexander H
dc.contributor.authorJee, Kyung-Wook
dc.contributor.authorLu, Hsiao-Ming
dc.date.accessioned2020-10-23T21:09:09Z
dc.date.available2020-10-23T21:09:09Z
dc.date.issued2020-03
dc.date.submitted2019-11
dc.identifier.issn0168-9002
dc.identifier.urihttps://hdl.handle.net/1721.1/128196
dc.description.abstractProton beam therapy is the current state of the art for irradiation of cancerous tumors near vital organs. Proton imaging is a new technology that images tumors with the same particle interaction as proton therapy, promising more accurate treatment preparation compared to traditional computerized tomography scans. A specific proton imaging technique in development at Massachusetts General Hospital requires an energy modulator that can fit inside the gantry nozzle. This work presents the design of a compact proton beam energy modulator required for such imaging applications. A combination of steel and lead wedges was used to create a balanced modulation wheel, with an axis of rotation perpendicular to the incident beam. The mechanical design also allows interchangeable disks and precise position control. The modulator design was verified by testing on a proton beam line. The final device achieved a wide range of energy modulation (21 cm water-equivalent thickness) while maintaining a constant exiting beam angular spread meeting device requirements. This compact design facilitates proton imaging to be practically incorporated into future gantry systems, which will advance proton treatment for tumors near vital organs.en_US
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.nima.2019.163269en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceProf. Slocumen_US
dc.titleDesign of a compact proton beam energy modulator for imagingen_US
dc.typeArticleen_US
dc.identifier.citationAggarwal, Neerja et al. "Design of a compact proton beam energy modulator for imaging." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 955 (March 2020): 163269 © 2019 Elsevier B.V.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratoryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.relation.journalNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipmenten_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2020-10-13T17:23:36Z
mit.journal.volume955en_US
mit.licensePUBLISHER_CC
mit.metadata.statusComplete


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