dc.contributor.author | Wong, Felix | |
dc.contributor.author | Collins, James J. | |
dc.date.accessioned | 2020-11-05T19:44:27Z | |
dc.date.available | 2020-11-05T19:44:27Z | |
dc.date.issued | 2020-11 | |
dc.date.submitted | 2020-09 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/128365 | |
dc.description.abstract | Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with interaction-based network models of disease transmission and show that superspreading, when it is fat-tailed, leads to pronounced transmission by increasing dispersion. Our findings indicate that large superspreading events should be the targets of interventions that minimize tail exposure. | en_US |
dc.language.iso | en | |
dc.publisher | National Academy of Sciences | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.2018490117 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PNAS | en_US |
dc.title | Evidence that coronavirus superspreading is fat-tailed | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Wong, Felix and James J. Collins. "Evidence that coronavirus superspreading is fat-tailed." Proceedings of the National Academy of Sciences (November 2020): dx.doi.org/10.1073/pnas.2018490117. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2020-11-05T13:20:56Z | |
dspace.orderedauthors | Wong, F; Collins, JJ | en_US |
dspace.date.submission | 2020-11-05T13:20:59Z | |
mit.license | PUBLISHER_POLICY | |
mit.metadata.status | Complete | |