Show simple item record

dc.contributor.authorWong, Felix
dc.contributor.authorCollins, James J.
dc.date.accessioned2020-11-05T19:44:27Z
dc.date.available2020-11-05T19:44:27Z
dc.date.issued2020-11
dc.date.submitted2020-09
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/1721.1/128365
dc.description.abstractSuperspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events are extremal, yet probable, occurrences. We integrate these results with interaction-based network models of disease transmission and show that superspreading, when it is fat-tailed, leads to pronounced transmission by increasing dispersion. Our findings indicate that large superspreading events should be the targets of interventions that minimize tail exposure.en_US
dc.language.isoen
dc.publisherNational Academy of Sciencesen_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.2018490117en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleEvidence that coronavirus superspreading is fat-taileden_US
dc.typeArticleen_US
dc.identifier.citationWong, Felix and James J. Collins. "Evidence that coronavirus superspreading is fat-tailed." Proceedings of the National Academy of Sciences (November 2020): dx.doi.org/10.1073/pnas.2018490117.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-11-05T13:20:56Z
dspace.orderedauthorsWong, F; Collins, JJen_US
dspace.date.submission2020-11-05T13:20:59Z
mit.licensePUBLISHER_POLICY
mit.metadata.statusComplete


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record