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dc.contributor.authorKay, Jennifer Elizabeth
dc.contributor.authorThadhani, Elina
dc.contributor.authorSamson, Leona D
dc.contributor.authorEngelward, Bevin P
dc.date.accessioned2020-11-23T21:38:14Z
dc.date.available2020-11-23T21:38:14Z
dc.date.issued2019-07
dc.date.submitted2019-06
dc.identifier.issn1568-7864
dc.identifier.urihttps://hdl.handle.net/1721.1/128611
dc.description.abstractThe relationships between inflammation and cancer are varied and complex. An important connection linking inflammation to cancer development is DNA damage. During inflammation reactive oxygen and nitrogen species (RONS) are created to combat pathogens and to stimulate tissue repair and regeneration, but these chemicals can also damage DNA, which in turn can promote mutations that initiate and promote cancer. DNA repair pathways are essential for preventing DNA damage from causing mutations and cytotoxicity, but RONS can interfere with repair mechanisms, reducing their efficacy. Further, cellular responses to DNA damage, such as damage signaling and cytotoxicity, can promote inflammation, creating a positive feedback loop. Despite coordination of DNA repair and oxidative stress responses, there are nevertheless examples whereby inflammation has been shown to promote mutagenesis, tissue damage, and ultimately carcinogenesis. Here, we discuss the DNA damage-mediated associations between inflammation, mutagenesis and cancer.en_US
dc.description.sponsorshipEPA Superfund Research Program (Grant P42ES027707)en_US
dc.description.sponsorshipNIEHS (Grant T32-ES007020)en_US
dc.description.sponsorshipNCI (Grant P01-CA026731)en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/J.DNAREP.2019.102673en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleInflammation-induced DNA damage, mutations and canceren_US
dc.typeArticleen_US
dc.identifier.citationKay, Jennifer Elizabeth et al. "Inflammation-induced DNA damage, mutations and cancer." DNA Repair 83 (November 2019): 102673 © 2019 Elsevier B.V.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.relation.journalDNA Repairen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-11-19T19:53:13Z
dspace.orderedauthorsKay, J; Thadhani, E; Samson, L; Engelward, Ben_US
dspace.date.submission2020-11-19T19:53:17Z
mit.journal.volume83en_US
mit.licensePUBLISHER_CC


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