dc.contributor.author | Ge, Zhongming | |
dc.contributor.author | Ge, Lili | |
dc.contributor.author | Muthupalani, Sureshkumar | |
dc.contributor.author | Feng, Yan | |
dc.contributor.author | Fox, James G | |
dc.date.accessioned | 2020-12-01T20:55:11Z | |
dc.date.available | 2020-12-01T20:55:11Z | |
dc.date.issued | 2020-11 | |
dc.date.submitted | 2020-11 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/128704 | |
dc.description.abstract | The prevalence of gastric Helicobacter pylori (Hp) infection is ~50% of the world population. However, how Hp infection influences inflammatory bowel disease in humans is not fully defined. In this study, we examined whether co-infection with Hp influenced Helicobacter hepaticus (Hh)–induced intestinal pathology in Rag2−/− mice. Rag2−/− mice of both sexes were infected with Hh, of which a subgroup was followed by infection with Hp two weeks later. Co-infected males, but not females, had significantly higher total colitis index scores in the colon at both 10 and 21 weeks post-Hh infection (WPI) and developed more severe dysplasia at 21 WPI compared with mono-Hh males. There were no significant differences in colonization levels of gastric Hp and colonic Hh between sexes or time-points. In addition, mRNA levels of colonic Il-1β, Ifnγ, Tnfα, Il-17A, Il-17F, Il-18, and Il-23, which play important roles in the development and function of proinflammatory innate lymphoid cell groups 1 and 3, were significantly up-regulated in the dually infected males compared with mono-Hh males at 21 WPI. These data suggest that concomitant Hp infection enhances the inflammatory responses in the colon of-Hh-infected Rag2−/− males, which results in more severe colitis and dysplasia. | en_US |
dc.description.sponsorship | National Institutes of Health (Grants P30-ES002109, P01 CA28842, R01OD11141 and R01CA093405) | en_US |
dc.publisher | MDPI AG | en_US |
dc.relation.isversionof | http://dx.doi.org/10.3390/ijms21238886 | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Multidisciplinary Digital Publishing Institute | en_US |
dc.title | Male-Dependent Promotion of Colitis in 129 Rag2−/− Mice Co-Infected with Helicobacter pylori and Helicobacter hepaticus | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Ge, Zhongming et al. "Male-Dependent Promotion of Colitis in 129 Rag2−/− Mice Co-Infected with Helicobacter pylori and Helicobacter hepaticus." International Journal of Molecular Sciences 21, 23 (November 2020): 8886 © 2020 The Authors. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Division of Comparative Medicine | en_US |
dc.relation.journal | International Journal of Molecular Sciences | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2020-11-26T14:09:25Z | |
dspace.date.submission | 2020-11-26T14:09:25Z | |
mit.journal.volume | 21 | en_US |
mit.journal.issue | 23 | en_US |
mit.license | PUBLISHER_CC | |
mit.metadata.status | Complete | |