K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Author(s)
Xiong, Aoli; Prakash, Prem; Gao, Xiaohong; Chew, Marvin; Tay, Jun Jie Ian; ... Show more
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Abstract
Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.
Date issued
2020-08
URI
https://hdl.handle.net/1721.1/128875
Department
Singapore-MIT Alliance in Research and Technology (SMART); Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Cell Reports
Publisher
Elsevier BV
Citation
Xiong, Aoli et al. "K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair." Cell Reports 32, 5 (August 2020): 107996 © 2020 The Author(s)
Version: Final published version
ISSN
2211-1247
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