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Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography

Author(s)
Braun, Phillip X.; Mehta, Nihaal; Gendelman, Isaac; Alibhai, A. Yasin; Moult, Eric Michael; Zhao, Yi; Ishibazawa, Akihiro; Sorour, Osama; Konstantinou, Eleni K.; Baumal, Caroline R.; Witkin, Andre J.; Fujimoto, James G; Duker, Jay S.; Waheed, Nadia K.; ... Show more Show less
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Abstract
PURPOSE: Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. METHODS: In this retrospective, cross-sectional study, 6 3 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and average flow deficit size. Regions were defined by concentric areas centered on the fovea: a 1-mm-diameter area, 3-mm-diameter ring, 5-mm-diameter area, 5-mm-diameter ring, and 6 3 6-mm whole image. Data were modeled using the generalized estimating equations approach. RESULTS: The relationship between age and CC FD% and average flow deficit size was statistically significant (P ≼ 0.05) in all regions of analysis by linear modeling. The relationship between dry AMD stage and FD% was statistically significant by linear modeling in the 5-mm ring, and between dry AMD stage and average flow deficit size in the 3-mm ring, 5-mm area, 5-mm ring, and 6 3 6-mm whole image. CONCLUSIONS. Linear modeling suggests a statistically significant relationship between dry AMD stage and CC perfusion, most prominent in the more peripheral regions of the macula.
Date issued
2019-12
URI
https://hdl.handle.net/1721.1/128928
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Journal
Investigative Ophthalmology and Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Braun, Phillip X. et al. "Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography." Investigative Ophthalmology and Visual Science 60, 15 (December 2019): 4985–4990. © 2019 The Authors
Version: Final published version
ISSN
1552-5783

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