Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
Author(s)Concellon Allueva, Alberto; San Anselmo, María; Hernández-Ainsa, Silvia; Romero, Pilar; Marcos, Mercedes; Serrano, José Luis; ... Show more Show less
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The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Concellón, Alberto et al. "Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties." Polymers 12, 12 (November 2020): 2872 © 2020 The Authors
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