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dc.contributor.authorIshibazawa, Akihiro
dc.contributor.authorDe Pretto, Lucas R.
dc.contributor.authorAlibhai, A. Yasin
dc.contributor.authorMoult, Eric M.
dc.contributor.authorArya, Malvika
dc.contributor.authorSorour, Osama
dc.contributor.authorMehta, Nihaal
dc.contributor.authorBaumal, Caroline R.
dc.contributor.authorWitkin, Andre J.
dc.contributor.authorYoshida, Akitoshi
dc.contributor.authorDuker, Jay S.
dc.contributor.authorFujimoto, James G.
dc.contributor.authorWaheed, Nadia K.
dc.date.accessioned2021-01-05T21:33:00Z
dc.date.available2021-01-05T21:33:00Z
dc.date.issued2019-10
dc.identifier.issn1552-5783
dc.identifier.urihttps://hdl.handle.net/1721.1/128962
dc.description.abstractCopyright 2019 The Authors PURPOSE. To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). METHODS. Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 3 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm that detects nonperfusion in full-retina OCT slabs was developed, and the percentages of capillary nonperfusion within the total image area were calculated. Retinal arteries and veins were manually traced. Based on the shortest distance, nonperfusion pixels were labeled as either arterial-side or venous-side. Arterial-adjacent and venous-adjacent nonperfusion and the A/V ratio (arterial-adjacent nonperfusion divided by venous-adjacent nonperfusion) were quantified. RESULTS. Twenty-two eyes with moderate NPDR, 16 eyes with severe NPDR, and 25 eyes with PDR were scanned. Total nonperfusion area in PDR (median: 8.93%) was greater than in moderate NPDR (3.49%, P < 0.01). Arterial-adjacent nonperfusion was greater than venous-adjacent nonperfusion for all stages of DR (P < 0.001). The median A/V ratios were 1.93 in moderate NPDR, 1.84 in severe NPDR, and 1.78 in PDR. The A/V ratio was negatively correlated with the total nonperfusion area (r ¼ -0.600, P < 0.0001). The results from the widefield montages showed similar patterns. CONCLUSIONS. OCTA images with arteries and veins traced allowed us to estimate the nonperfusion distribution. In DR, smaller nonperfusion tends to be arterial-adjacent, while larger nonperfusion tends toward veins.en_US
dc.language.isoen
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1167/iovs.19-26653en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceInvestigative Ophthalmology & Visual Scienceen_US
dc.titleRetinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathyen_US
dc.typeArticleen_US
dc.identifier.citationIshibazawa, Akihiro et al. "Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy." Investigative Ophthalmology and Visual Science 60, 13 (October 2019): 4310-4318 © 2019 The Authorsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.relation.journalInvestigative Ophthalmology and Visual Scienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-12-14T20:13:31Z
dspace.orderedauthorsIshibazawa, A; De Pretto, LR; Alibhai, AY; Moult, EM; Arya, M; Sorour, O; Mehta, N; Baumal, CR; Witkin, AJ; Yoshida, A; Duker, JS; Fujimoto, JG; Waheed, NKen_US
dspace.date.submission2020-12-14T20:13:37Z
mit.journal.volume60en_US
mit.journal.issue13en_US
mit.licensePUBLISHER_CC


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