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Vibrating dichroic MEMS scanner based line scan multiphoton endomicroscope

Author(s)
Xu, Yingshun; Cheng, Jin; Xu, Naitao; Zhu, Lanping; Cao, Yuzhu; Fang, Bei; Chen, Xin; Wang, Suogang; So, Peter T. C.; ... Show more Show less
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Abstract
To achieve optical biopsy for gastro-intestinal (GI) endosopy with the use of nonlinear optical (NLO) endomicroscopes, integration of NLO technology with the design of a conventional flexible GI endoscope is necessary. One key challenge has been to design an NLO distal tip which can be compatible with flexible GI endoscopy retroflexion curvature radius as small as 20 mm to provide bending angle up to 210 degrees; the state-of-the-art NLO miniaturized design still consists of a long rigid "needle" shape probe at the distal end that can be damaged during the retroflex procedure when passing through the instrument channel of a flexible GI endoscope for in vivo imaging. To circumvent this design challenge, authors present a line scan multiphoton endomicroscope utilizing a novel simplified microelectromechanical systems (MEMS) scanner. This unique MEMS scanner consists of a customized single-axis dichroic MEMS scanner (SADMS) and vibrates at the back focal point of a customized micro-objective lens. This work demonstrates the new NLO scanner design can be compatible with conventional flexible GI endoscope to offer in situ functional microscopic imaging capability.
Date issued
2019-03
URI
https://hdl.handle.net/1721.1/129460
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
Proceedings of SPIE
Publisher
Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation
Xu, Yingshun et al. "Vibrating dichroic MEMS scanner based line scan multiphoton endomicroscope." MOEMS and Miniaturized Systems XVIII, Proceedings of SPIE 10931, 1093116 (12 pages). © 2019 SPIE
Version: Final published version
ISBN
9781510625044
9781510625051

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