| dc.contributor.author | Lee, Sharon Wei Ling | |
| dc.contributor.author | Paoletti, Camilla | |
| dc.contributor.author | Campisi, Marco | |
| dc.contributor.author | Osaki, Tatsuya | |
| dc.contributor.author | Adriani, Giulia | |
| dc.contributor.author | Kamm, Roger Dale | |
| dc.contributor.author | Mattu, Clara | |
| dc.contributor.author | Chiono, Valeria | |
| dc.date.accessioned | 2021-01-20T18:56:01Z | |
| dc.date.available | 2021-01-20T18:56:01Z | |
| dc.date.issued | 2019-11 | |
| dc.date.submitted | 2019-10 | |
| dc.identifier.issn | 0168-3659 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/129476 | |
| dc.description.abstract | MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine. | en_US |
| dc.description.sponsorship | National Science Foundation (Grant CBET-0939511) | en_US |
| dc.description.sponsorship | National Cancer Institute (Grant U01-CA214381-01) | en_US |
| dc.language.iso | en | |
| dc.publisher | Elsevier BV | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.jconrel.2019.10.007 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | Elsevier | en_US |
| dc.title | MicroRNA delivery through nanoparticles | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Lee, Sharon Wei Ling et al. "MicroRNA delivery through nanoparticles." Journal of Controlled Release 313 (November 2019): 80-95 © 2019 The Authors | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.relation.journal | Journal of Controlled Release | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2020-08-17T17:02:19Z | |
| dspace.date.submission | 2020-08-17T17:02:23Z | |
| mit.journal.volume | 313 | en_US |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Complete | |
