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Optical coherence tomography angiography (OCTA) flow speed mapping technology for retinal diseases

Author(s)
Waheed, Nadia K; Moult, Eric Michael; Fujimoto, James G
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Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
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Abstract
Introduction: Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality for depth-resolved visualization of retinal vasculature. Angiographic data couples with structural data to generate a cube scan, from which en-face images of vasculature can be obtained at various axial positions. OCTA has expanded understanding of retinal vascular disorders and has primarily been used for qualitative analysis. Areas covered: Recent studies have explored the quantitative properties of OCTA, which would allow for objective assessment and follow-up of retinal pathologies. Various quantitative metrics have been developed, such as foveal avascular zone area and vessel density. However, quantitative assessment of the characteristics of retinal blood flow remains limited, as OCTA provides an image depicting either the presence or absence of flow at a particular region without information of relative velocities. The development of variable interscan time analysis (VISTA) overcomes this limitation. The VISTA algorithm generates a color-coded map of relative blood flow speeds. VISTA has already demonstrated utility in furthering our understanding of various retinal pathologies, such as geographic atrophy, choroidal neovascularization, aneurysmal type 1 neovascularization, and diabetic retinopathy. Expert commentary: VISTA, an OCTA flow speed mapping technique, may have a role in developing the utility of OCTA as a screening tool.
Date issued
2018-12
URI
https://hdl.handle.net/1721.1/129648
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Expert Review of Medical Devices
Publisher
Taylor & Francis
Citation
Arya, Malvika et al. “Optical coherence tomography angiography (OCTA) flow speed mapping technology for retinal diseases.” Expert Review of Medical Devices, 15, 12 (December 2018): 875–882 © 2018 The Author(s)
Version: Author's final manuscript
ISSN
1743-4440

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