Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
dc.contributor.author | Mercado, Noe B. | |
dc.contributor.author | Zahn, Roland | |
dc.contributor.author | Wegmann, Frank | |
dc.contributor.author | Loos, Carolin | |
dc.contributor.author | Chandrashekar, Abishek | |
dc.contributor.author | Yu, Jingyou | |
dc.contributor.author | Liu, Jinyan | |
dc.contributor.author | Peter, Lauren | |
dc.contributor.author | McMahan, Katherine | |
dc.contributor.author | Tostanoski, Lisa H. | |
dc.contributor.author | He, Xuan | |
dc.contributor.author | Martinez, David R. | |
dc.contributor.author | Rutten, Lucy | |
dc.contributor.author | Bos, Rinke | |
dc.contributor.author | van Manen, Danielle | |
dc.contributor.author | Vellinga, Jort | |
dc.contributor.author | Custers, Jerome | |
dc.contributor.author | Langedijk, Johannes P. | |
dc.contributor.author | Kwaks, Ted | |
dc.contributor.author | Bakkers, Mark J. G. | |
dc.contributor.author | Zuijdgeest, David | |
dc.contributor.author | Rosendahl Huber, Sietske K. | |
dc.contributor.author | Atyeo, Caroline | |
dc.contributor.author | Fischinger, Stephanie | |
dc.contributor.author | Burke, John | |
dc.contributor.author | Feldman, Jared | |
dc.contributor.author | Hauser, Blake Marie | |
dc.contributor.author | Caradonna, Timothy M. | |
dc.contributor.author | Bondzie, Esther A. | |
dc.contributor.author | Dagotto, Gabriel | |
dc.contributor.author | Gebre, Makda S. | |
dc.contributor.author | Hoffman, Emily | |
dc.contributor.author | Jacob-Dolan, Catherine | |
dc.contributor.author | Kirilova, Marinela | |
dc.contributor.author | Li, Zhenfeng | |
dc.contributor.author | Lin, Zijin | |
dc.contributor.author | Mahrokhian, Shant H. | |
dc.contributor.author | Maxfield, Lori F. | |
dc.contributor.author | Nampanya, Felix | |
dc.contributor.author | Nityanandam, Ramya | |
dc.contributor.author | Nkolola, Joseph P. | |
dc.contributor.author | Patel, Shivani | |
dc.contributor.author | Ventura, John D. | |
dc.contributor.author | Verrington, Kaylee | |
dc.contributor.author | Wan, Huahua | |
dc.contributor.author | Pessaint, Laurent | |
dc.contributor.author | Van Ry, Alex | |
dc.contributor.author | Blade, Kelvin | |
dc.contributor.author | Strasbaugh, Amanda | |
dc.contributor.author | Cabus, Mehtap | |
dc.contributor.author | Brown, Renita | |
dc.contributor.author | Cook, Anthony | |
dc.contributor.author | Zouantchangadou, Serge | |
dc.contributor.author | Teow, Elyse | |
dc.contributor.author | Andersen, Hanne | |
dc.contributor.author | Lewis, Mark G. | |
dc.contributor.author | Cai, Yongfei | |
dc.contributor.author | Chen, Bing | |
dc.contributor.author | Schmidt, Aaron G. | |
dc.contributor.author | Reeves, R. Keith | |
dc.contributor.author | Baric, Ralph S. | |
dc.contributor.author | Lauffenburger, Douglas A. | |
dc.contributor.author | Alter, Galit | |
dc.contributor.author | Stoffels, Paul | |
dc.contributor.author | Mammen, Mathai | |
dc.contributor.author | Van Hoof, Johan | |
dc.contributor.author | Schuitemaker, Hanneke | |
dc.contributor.author | Barouch, Dan | |
dc.date.accessioned | 2021-02-04T17:02:21Z | |
dc.date.available | 2021-02-04T17:02:21Z | |
dc.date.issued | 2020-07 | |
dc.date.submitted | 2020-06 | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.issn | 1476-4687 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/129676 | |
dc.description.abstract | A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1–8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials. | en_US |
dc.language.iso | en | |
dc.publisher | Springer Science and Business Media LLC | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/s41586-020-2607-z | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Mercado, Noe B. et al. "Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques." Nature 586, 7830 (October 2020): 583–588 © 2020 The Author(s) | en_US |
dc.contributor.department | Ragon Institute of MGH, MIT and Harvard | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.relation.journal | Nature | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2021-02-03T15:25:14Z | |
dspace.orderedauthors | Mercado, NB; Zahn, R; Wegmann, F; Loos, C; Chandrashekar, A; Yu, J; Liu, J; Peter, L; McMahan, K; Tostanoski, LH; He, X; Martinez, DR; Rutten, L; Bos, R; van Manen, D; Vellinga, J; Custers, J; Langedijk, JP; Kwaks, T; Bakkers, MJG; Zuijdgeest, D; Rosendahl Huber, SK; Atyeo, C; Fischinger, S; Burke, JS; Feldman, J; Hauser, BM; Caradonna, TM; Bondzie, EA; Dagotto, G; Gebre, MS; Hoffman, E; Jacob-Dolan, C; Kirilova, M; Li, Z; Lin, Z; Mahrokhian, SH; Maxfield, LF; Nampanya, F; Nityanandam, R; Nkolola, JP; Patel, S; Ventura, JD; Verrington, K; Wan, H; Pessaint, L; Van Ry, A; Blade, K; Strasbaugh, A; Cabus, M; Brown, R; Cook, A; Zouantchangadou, S; Teow, E; Andersen, H; Lewis, MG; Cai, Y; Chen, B; Schmidt, AG; Reeves, RK; Baric, RS; Lauffenburger, DA; Alter, G; Stoffels, P; Mammen, M; Van Hoof, J; Schuitemaker, H; Barouch, DH | en_US |
dspace.date.submission | 2021-02-03T15:25:16Z | |
mit.journal.volume | 586 | en_US |
mit.journal.issue | 7830 | en_US |
mit.license | PUBLISHER_POLICY | |
mit.metadata.status | Complete |