Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity
Author(s)Uhler, Caroline; Shivashankar, G.V.
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In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions. In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium. This emphasizes the need for integrating material properties of tissues in drug discovery programs.
DepartmentMassachusetts Institute of Technology. Laboratory for Information and Decision Systems
Current Opinion in Solid State and Materials Science
Uhler, Caroline and G. V. Shivashankar. "Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity." Current Opinion in Solid State and Materials Science 25, 1 (February 2021): 100874.
Author's final manuscript