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dc.contributor.authorUhler, Caroline
dc.contributor.authorShivashankar, G.V.
dc.date.accessioned2021-03-11T21:42:37Z
dc.date.available2021-03-11T21:42:37Z
dc.date.issued2018-04
dc.identifier.issn2405-8033
dc.identifier.urihttps://hdl.handle.net/1721.1/130125
dc.description.abstractAbnormalities in nuclear and chromatin organization are hallmarks of many diseases including cancer. This review provides our understanding of how the cellular microenvironment regulates nuclear morphology and with it the spatial organization of chromosomes and genes, resulting in cell-type specific genomic programs. We also discuss the molecular basis for maintaining nuclear and genomic integrity and how alterations in nuclear mechanotransduction pathways result in various diseases. Finally, we highlight the importance of digital pathology based on nuclear morphometric features combined with single-cell genomics for early cancer diagnostics.en_US
dc.description.sponsorshipNSF (Grant DMS-1651995)en_US
dc.description.sponsorshipONR (Grant N00014-17-1-2147)en_US
dc.publisherElsevier BVen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.trecan.2018.02.009en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceProf. Uhler via Phoebe Ayersen_US
dc.titleNuclear Mechanopathology and Cancer Diagnosisen_US
dc.typeArticleen_US
dc.identifier.citationUhler, Caroline and G.V. Shivashankar. "Nuclear Mechanopathology and Cancer Diagnosis." Trends in Cancer 4, 4 (April 2018): P320-331.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Laboratory for Information and Decision Systemsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Data, Systems, and Societyen_US
dc.relation.journalTrends in Canceren_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2021-03-05T17:29:51Z
mit.journal.volume4en_US
mit.journal.issue4en_US
mit.licensePUBLISHER_CC


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