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dc.contributor.authorLi, Yinqing
dc.contributor.authorLopez Huerta, Violeta
dc.contributor.authorAdiconis, Xian
dc.contributor.authorLevandowski, Kirsten
dc.contributor.authorChoi, Soonwook
dc.contributor.authorSimmons, Sean K.
dc.contributor.authorArias-Garcia, Mario A.
dc.contributor.authorGuo, Baolin
dc.contributor.authorYao, Annie
dc.contributor.authorBlosser, Timothy R.
dc.contributor.authorWimmer, Ralf D
dc.contributor.authorAida, Tomomi
dc.contributor.authorAtamian, Alexander
dc.contributor.authorNaik, Tina
dc.contributor.authorSun, Xuyun
dc.contributor.authorBi, Dasheng
dc.contributor.authorMalhotra, Diya
dc.contributor.authorHession, Cynthia C.
dc.contributor.authorShema Tirosh, Reut
dc.contributor.authorGomes, Marcos
dc.contributor.authorLi, Taibo
dc.contributor.authorHwang, Eunjin
dc.contributor.authorKrol, Alexandra
dc.contributor.authorKowalczyk, Monika
dc.contributor.authorPeça, João
dc.contributor.authorPan, Gang
dc.contributor.authorHalassa, Michael
dc.contributor.authorLevin, Joshua Z.
dc.contributor.authorFu, Zhanyan
dc.contributor.authorFeng, Guoping
dc.date.accessioned2021-04-07T21:02:09Z
dc.date.available2021-04-07T21:02:09Z
dc.date.issued2020-07
dc.date.submitted2019-05
dc.identifier.issn0028-0836
dc.identifier.issn1476-4687
dc.identifier.urihttps://hdl.handle.net/1721.1/130405
dc.description.abstractThe thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates thalamocortical interactions that are critical for sensory processing, attention and cognition1–5. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders6–9. However, little is known about the organizational principles that underlie its divergent functions. Here we performed an integrative study linking single-cell molecular and electrophysiological features of the mouse TRN to connectivity and systems-level function. We found that cellular heterogeneity in the TRN is characterized by a transcriptomic gradient of two negatively correlated gene-expression profiles, each containing hundreds of genes. Neurons in the extremes of this transcriptomic gradient express mutually exclusive markers, exhibit core or shell-like anatomical structure and have distinct electrophysiological properties. The two TRN subpopulations make differential connections with the functionally distinct first-order and higher-order thalamic nuclei to form molecularly defined TRN–thalamus subnetworks. Selective perturbation of the two subnetworks in vivo revealed their differential role in regulating sleep. In sum, our study provides a comprehensive atlas of TRN neurons at single-cell resolution and links molecularly defined subnetworks to the functional organization of thalamocortical circuits.en_US
dc.description.sponsorshipNIH/NIMH (Grants R01NS098505, R01NS113245)en_US
dc.description.sponsorshipNIH (Grants R01NS098505, R01MH107680)en_US
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/s41586-020-2504-5en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleDistinct subnetworks of the thalamic reticular nucleusen_US
dc.typeArticleen_US
dc.identifier.citationLi, Yinqing et al. "Distinct subnetworks of the thalamic reticular nucleus." Nature 583, 7818 (July 2020): 819–824. © 2020 The Author(s)en_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentKlarman Cell Observatory (Broad Institute)en_US
dc.relation.journalNatureen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-04-06T18:50:09Z
dspace.orderedauthorsLi, Y; Lopez-Huerta, VG; Adiconis, X; Levandowski, K; Choi, S; Simmons, SK; Arias-Garcia, MA; Guo, B; Yao, AY; Blosser, TR; Wimmer, RD; Aida, T; Atamian, A; Naik, T; Sun, X; Bi, D; Malhotra, D; Hession, CC; Shema, R; Gomes, M; Li, T; Hwang, E; Krol, A; Kowalczyk, M; Peça, J; Pan, G; Halassa, MM; Levin, JZ; Fu, Z; Feng, Gen_US
dspace.date.submission2021-04-06T18:50:10Z
mit.journal.volume583en_US
mit.journal.issue7818en_US
mit.licensePUBLISHER_POLICY
mit.metadata.statusAuthority Work and Publication Information Needed


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