Search
Now showing items 11-20 of 122
Tools and reference standards supporting the engineering and evolution of synthetic biological systems
(Massachusetts Institute of Technology, 2008)
Biological engineers have constructed a number of multi-part synthetic biological systems that conduct logical operations on input signals, produce oscillatory output signals, store memory, or produce desired products. ...
In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression
(Massachusetts Institute of Technology, 2003)
Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds ...
Nanoscale and microscale approaches for engineering the in vitro cellular microenvironment
(Massachusetts Institute of Technology, 2005)
Micro- and nanofabrication approaches have dramatically changed our society through their use in microelectronics and telecommunication industries. These engineering tools are also useful for many biological applications ...
Cartilage mechanobiology : the effects of loading on the fine structure and function of chondroitin sulfate glycosaminoglycans
(Massachusetts Institute of Technology, 2005)
Chondroitin sulfate is a critical component of articular cartilage due to its contribution to the tissue's resistance to compressive deformation. Alterations in the biosynthesis of this molecule over time could impact the ...
Quantitative imaging of living cells by deep ultraviolet microscopy
(Massachusetts Institute of Technology, 2006)
Developments in light microscopy over the past three centuries have opened new windows into cell structure and function, yet many questions remain unanswered by current imaging approaches. Deep ultraviolet microscopy ...
Scalable computational architecture for integrating biological pathway models
(Massachusetts Institute of Technology, 2007)
A grand challenge of systems biology is to model the cell. The cell is an integrated network of cellular functions. Each cellular function, such as immune response, cell division, metabolism or apoptosis, is defined by an ...
Biophysical characterization of high affinity engineered single chain Fv antibody fragments
(Massachusetts Institute of Technology, 2004)
High affinity antibody binding interactions are important for both pharmaceutical and biotechnological uses. However, designing higher affinity interactions has remained difficult. Both high affinity interactions from ...
Investigations into therapeutic discovery and delivery of heparin-like glycosaminoglycans
(Massachusetts Institute of Technology, 2001)
Heparin-like glycosaminoglycans (HLGAGs) are complex polysaccharides found both in extracellular matrix (ECM) and at the cell surface where they, in a sequence-specific manner, bind to and regulate the biological activity ...
Nucleobase deamination as a biomarker of inflammatory processes
(Massachusetts Institute of Technology, 2005)
(cont.) kinetic studies. Moderate increases ([approximately]30%) in nucleobase deamination products were observed in the SJL mice bearing the RcsX tumor, but the biological meaning of these increases awaits studies of DNA ...
Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
(Massachusetts Institute of Technology, 2009)
The inability of articular cartilage to heal after damage or disease has motivated investigation of novel cartilage tissue engineering technologies. The objective of this thesis was to advance the use of self-assembling ...