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dc.contributor.authorOverholt, Kalon J.
dc.contributor.authorKrog, Jonathan R.
dc.contributor.authorZanoni, Ivan
dc.contributor.authorBryson, Bryan D.
dc.date.accessioned2021-07-20T21:58:35Z
dc.date.available2021-07-20T21:58:35Z
dc.date.issued2021-07
dc.date.submitted2021-03
dc.identifier.urihttps://hdl.handle.net/1721.1/131120
dc.description.abstractSevere COVID-19 is accompanied by rampant immune dysregulation in the lung and periphery, with immune cells of both compartments contributing to systemic distress. The extent to which immune cells of the lung and blood enter similar or distinct pathological states during severe disease remains unknown. Here, we leveraged 96 publicly available single-cell RNA sequencing datasets to elucidate common and compartment-specific features of severe to critical COVID-19 at the levels of transcript expression, biological pathways, and ligand-receptor signaling networks. Comparing severe patients to milder and healthy donors, we identified distinct differential gene expression signatures between compartments and a core set of co-directionally regulated surface markers. A majority of severity-enriched pathways were shared, whereas TNF and interferon responses were polarized. Severity-specific ligand-receptor networks appeared to be differentially active in both compartments. Overall, our results describe a nuanced response during severe COVID-19 where compartment plays a role in dictating the pathological state of immune cells.en_US
dc.description.sponsorshipNational Science Foundation (Grant 1745302)en_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://dx.doi.org/10.1016/j.isci. 2021.102738en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceElsevieren_US
dc.titleDissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolutionen_US
dc.typeArticleen_US
dc.identifier.citationOverholt, Kalon J. et al. "Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution." Cell 24, 7 (July 2021): 102738. © 2021 The Authorsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentRagon Institute of MGH, MIT and Harvarden_US
dc.relation.journalCellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2021-07-19T14:53:57Z
mit.journal.volume24en_US
mit.journal.issue7en_US
mit.licensePUBLISHER_CC
mit.metadata.statusComplete


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