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dc.contributor.authorLi, Jonathan
dc.contributor.authorFraenkel, Ernest
dc.date.accessioned2021-09-16T14:50:35Z
dc.date.available2021-09-16T14:50:35Z
dc.date.issued2021-07
dc.identifier.issn2574-3414
dc.identifier.issn2574-3414
dc.identifier.urihttps://hdl.handle.net/1721.1/131273
dc.description.abstractInduced pluripotent stem cell (iPSC) technology holds promise for modeling neurodegenerative diseases. Traditional approaches for disease modeling using animal and cellular models require knowledge of disease mutations. However, many patients with neurodegenerative diseases do not have a known genetic cause. iPSCs offer a way to generate patient-specific models and study pathways of dysfunction in an in vitro setting in order to understand the causes and subtypes of neurodegeneration. Furthermore, iPSC-based models can be used to search for candidate therapeutics using high-throughput screening. Here we review how iPSC-based models are currently being used to further our understanding of neurodegenerative diseases, as well as discuss their challenges and future directions.en_US
dc.language.isoen
dc.publisherAnnual Reviewsen_US
dc.relation.isversionofhttp://dx.doi.org/10.1146/annurev-biodatasci-092820-025214en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Fraenkelen_US
dc.titlePhenotyping Neurodegeneration in Human iPSCsen_US
dc.typeArticleen_US
dc.identifier.citationLi, Jonathan and Ernest Fraenkel. "Phenotyping Neurodegeneration in Human iPSCs." Annual Review of Biomedical Data Science 4, 1 (July 2021): 83-100.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Computational and Systems Biology Programen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.relation.journalAnnual Review of Biomedical Data Scienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-09-15T16:37:10Z
dspace.orderedauthorsLi, J; Fraenkel, Een_US
dspace.date.submission2021-09-15T16:37:12Z
mit.journal.volume4en_US
mit.journal.issue1en_US
mit.licenseOPEN_ACCESS_POLICY
mit.metadata.statusCompleteen_US


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