Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device
Author(s)
Kim, Jaehoon; Yoon, Junghyo; Byun, Jae-Yeong; Kim, Hyunho; Han, Sewoon; Kim, Junghyun; Lee, Jeong Hoon; Jo, Han-Sang; Chung, Seok; ... Show more Show less
Downloadsensors-21-01366-v2.pdf (2.042Mb)
Publisher with Creative Commons License
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μL of extracted plasma with a high extraction yield (~45%) in 16 min.
Date issued
2021-02-15Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer SciencePublisher
Multidisciplinary Digital Publishing Institute
Citation
Sensors 21 (4): 1366 (2021)
Version: Final published version