Show simple item record

dc.contributor.authorFeng, Mengling
dc.contributor.authorMcSparron, Jakob I
dc.contributor.authorKien, Dang T
dc.contributor.authorStone, David J
dc.contributor.authorRoberts, David H
dc.contributor.authorSchwartzstein, Richard M
dc.contributor.authorVieillard-Baron, Antoine
dc.contributor.authorCeli, Leo A
dc.date.accessioned2021-09-20T17:17:02Z
dc.date.available2021-09-20T17:17:02Z
dc.date.issued2018-05-28
dc.identifier.urihttps://hdl.handle.net/1721.1/131429
dc.description.abstractAbstract Purpose While the use of transthoracic echocardiography (TTE) in the ICU is rapidly expanding, the contribution of TTE to altering patient outcomes among ICU patients with sepsis has not been examined. This study was designed to examine the association of TTE with 28-day mortality specifically in that population. Methods and results The MIMIC-III database was employed to identify patients with sepsis who had and had not received TTE. The statistical approaches utilized included multivariate regression, propensity score analysis, doubly robust estimation, the gradient boosted model, and an inverse probability-weighting model to ensure the robustness of our findings. Significant benefit in terms of 28-day mortality was observed among the TTE patients compared to the control (no TTE) group (odds ratio = 0.78, 95% CI 0.68–0.90, p < 0.001). The amount of fluid administered (2.5 vs. 2.1 L on day 1, p < 0.001), use of dobutamine (2% vs. 1%, p = 0.007), and the maximum dose of norepinephrine (1.4 vs. 1 mg/min, p = 0.001) were significantly higher for the TTE patients. Importantly, the TTE patients were weaned off vasopressors more quickly than those in the no TTE group (vasopressor-free days on day 28 of 21 vs. 19, p = 0.004). Conclusion In a general population of critically ill patients with sepsis, use of TTE is associated with an improvement in 28-day mortality.en_US
dc.publisherSpringer Berlin Heidelbergen_US
dc.relation.isversionofhttps://doi.org/10.1007/s00134-018-5208-7en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSpringer Berlin Heidelbergen_US
dc.titleTransthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III databaseen_US
dc.typeArticleen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Science
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-09-24T20:45:07Z
dc.language.rfc3066en
dc.rights.holderSpringer-Verlag GmbH Germany, part of Springer Nature and ESICM
dspace.embargo.termsY
dspace.date.submission2020-09-24T20:45:06Z
mit.licensePUBLISHER_POLICY
mit.metadata.statusAuthority Work and Publication Information Needed


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record