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dc.contributor.authorGleason, Karen K
dc.date.accessioned2021-09-22T14:43:51Z
dc.date.available2021-09-22T14:43:51Z
dc.date.issued2021-01
dc.date.submitted2020-11
dc.identifier.issn2296-4185
dc.identifier.urihttps://hdl.handle.net/1721.1/132624
dc.description.abstractThis review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release.en_US
dc.publisherFrontiers Media SAen_US
dc.relation.isversionofhttps://doi.org/10.3389/fbioe.2021.632753en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceFrontiersen_US
dc.titleControlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayersen_US
dc.typeArticleen_US
dc.identifier.citationGleason, Karen K. "Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers." Frontiers in Bioengineering and Biotechnology (January 2021): 632753. © 2021 Gleasonen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.relation.journalFrontiers in Bioengineering and Biotechnologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2021-04-28T13:43:44Z
mit.journal.volume9en_US
mit.licensePUBLISHER_CC
mit.metadata.statusCompleteen_US


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