Show simple item record

dc.contributor.authorKim, Seok
dc.contributor.authorKim, Woo Young
dc.contributor.authorNam, Sang-Hoon
dc.contributor.authorShin, Seunghang
dc.contributor.authorChoi, Su Hyun
dc.contributor.authorKim, Do Hyeog
dc.contributor.authorLee, Heedoo
dc.contributor.authorChoi, Hyeok Jae
dc.contributor.authorLee, Eungman
dc.contributor.authorPark, Jung-Hyun
dc.contributor.authorJo, Inho
dc.contributor.authorFang, Nicholas Xuanlai
dc.contributor.authorCho, Young Tae
dc.date.accessioned2021-10-05T13:55:47Z
dc.date.available2021-10-05T13:55:47Z
dc.date.issued2021-08
dc.date.submitted2021-02
dc.identifier.issn1936-0851
dc.identifier.issn1936-086X
dc.identifier.urihttps://hdl.handle.net/1721.1/132715
dc.description.abstractEvaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces. For the proof-of-concept, interconnected hexagonal and inverted pyramidal microwall were fabricated using ultraviolet-based nanoimprint lithography, which is considered to be a promising scalable manufacturing process. We demonstrated the potentials of an engineered microcavity surface to limit the contact transfer of particle aggregates deposited with the evaporation of microdroplets by 93% for hexagonal microwall and by 96% for inverted pyramidal microwall. The particle capture potential of the interconnected microstructures was also investigated using biological particles, including adenoviruses and lung-derived extracellular vesicles. The findings indicate that the proposed microstructured surfaces can reduce the indirect fomite transmission of highly infectious agents, including norovirus, rotavirus, or SARS-CoV-2, via respiratory droplets.en_US
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acsnano.1c01636en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceACSen_US
dc.titleMicrostructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Dropletsen_US
dc.typeArticleen_US
dc.identifier.citationKim, Seok et al. "Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets." ACS Nano 15, 9 (August 2021): 14049−14060. © 2021 The Authorsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.relation.journalACS Nanoen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-10-04T16:18:41Z
dspace.orderedauthorsKim, S; Kim, WY; Nam, S-H; Shin, S; Choi, SH; Kim, DH; Lee, H; Choi, HJ; Lee, E; Park, J-H; Jo, I; Fang, NX; Cho, YTen_US
dspace.date.submission2021-10-04T16:18:43Z
mit.journal.volume15en_US
mit.journal.issue9en_US
mit.licensePUBLISHER_CC
mit.metadata.statusCompleteen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record