dc.contributor.author | Graff, Rebecca E. | |
dc.contributor.author | Ahearn, Thomas U. | |
dc.contributor.author | Pettersson, Andreas | |
dc.contributor.author | Ebot, Ericka M. | |
dc.contributor.author | Gerke, Travis | |
dc.contributor.author | Penney, Kathryn L. | |
dc.contributor.author | Wilson, Kathryn M. | |
dc.contributor.author | Markt, Sarah C. | |
dc.contributor.author | Pernar, Claire H. | |
dc.contributor.author | Gonzalez-Feliciano, Amparo G. | |
dc.contributor.author | Song, Mingyang | |
dc.contributor.author | Lis, Rosina T. | |
dc.contributor.author | Schmidt, Daniel R. | |
dc.contributor.author | Vander Heiden, Matthew G. | |
dc.contributor.author | Fiorentino, Michelangelo | |
dc.contributor.author | Giovannucci, Edward L. | |
dc.contributor.author | Loda, Massimo | |
dc.contributor.author | Mucci, Lorelei A. | |
dc.date.accessioned | 2022-02-09T16:50:59Z | |
dc.date.available | 2021-10-27T19:53:27Z | |
dc.date.available | 2022-02-09T16:50:59Z | |
dc.date.issued | 2017-11 | |
dc.date.submitted | 2017-09 | |
dc.identifier.issn | 1055-9965 | |
dc.identifier.issn | 1538-7755 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/133545.2 | |
dc.description.abstract | © 2017 American Association for Cancer Research. Background: The largest molecular subtype of primary prostate cancer is defined by the TMPRSS2:ERG gene fusion. Few studies, however, have investigated etiologic differences by TMPRSS2:ERG status. Because the fusion is hormone-regulated and a man's hormonal milieu varies by height and obesity status, we hypothesized that both May be differentially associated with risk of TMPRSS2:ERG-defined disease. Methods: Our study included 49,372 men from the prospective Health Professionals Follow-up Study. Participants reported height and weight at baseline in 1986 and updated weight biennially thereafter through 2009. Tumor ERG protein expression (a TMPRSS2:ERG marker) was immuno-histochemically assessed. We used multivariable competing risks models to calculate HRs and 95% confidence intervals (CIs) for the risk of ERG-positive and ERG-negative prostate cancer. Results: During 23 years of follow-up, we identified 5,847 incident prostate cancers, among which 913 were ERG-assayed. Taller height was associated with an increased risk of ERG-positive disease only [per 5 inches HR 1.24; 95% confidence interval (CI), 1.03–1.50; Pheterogeneity ¼ 0.07]. Higher body mass index (BMI) at baseline (per 5 kg/m2 HR 0.75; 95% CI, 0.61–0.91; Pheterogeneity ¼ 0.02) and updated BMI over time (per 5 kg/m2 HR 0.86; 95% CI, 0.74–1.00; Pheterogeneity ¼ 0.07) were associated with a reduced risk of ERG-positive disease only. Conclusions: Our results indicate that anthropometrics May be uniquely associated with TMPRSS2:ERG-positive prostate cancer; taller height May be associated with greater risk, whereas obesity May be associated with lower risk. Impact: Our study provides strong rationale for further investigations of other prostate cancer risk factors that May be distinctly associated with subtypes. Cancer Epidemiol Biomarkers Prev; 27(2); 193–200. 2017 AACR. | en_US |
dc.language.iso | en | |
dc.publisher | American Association for Cancer Research (AACR) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1158/1055-9965.epi-17-0547 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Height, Obesity, and the Risk of TMPRSS2:ERG-Defined Prostate Cancer | en_US |
dc.type | Article | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | |
dc.relation.journal | Cancer Epidemiology Biomarkers and Prevention | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2021-08-03T15:43:39Z | |
dspace.orderedauthors | Graff, RE; Ahearn, TU; Pettersson, A; Ebot, EM; Gerke, T; Penney, KL; Wilson, KM; Markt, SC; Pernar, CH; Gonzalez-Feliciano, AG; Song, M; Lis, RT; Schmidt, DR; Vander Heiden, MG; Fiorentino, M; Giovannucci, EL; Loda, M; Mucci, LA | en_US |
dspace.date.submission | 2021-08-03T15:43:41Z | |
mit.journal.volume | 27 | en_US |
mit.journal.issue | 2 | en_US |
mit.license | OPEN_ACCESS_POLICY | |
mit.metadata.status | Authority Work Needed | en_US |