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dc.contributor.authorMichelow, Ian C
dc.contributor.authorPark, Sangshin
dc.contributor.authorTsai, Shu-Whei
dc.contributor.authorRayta, Bonnie
dc.contributor.authorPasaje, Charisse Flerida A
dc.contributor.authorNelson, Sara
dc.contributor.authorEarly, Angela M
dc.contributor.authorFrosch, Anne P
dc.contributor.authorAyodo, George
dc.contributor.authorRaj, Dipak K
dc.contributor.authorNixon, Christina E
dc.contributor.authorNixon, Christian P
dc.contributor.authorPond-Tor, Sunthorn
dc.contributor.authorFriedman, Jennifer F
dc.contributor.authorFried, Michal
dc.contributor.authorDuffy, Patrick E
dc.contributor.authorLe Roch, Karine G
dc.contributor.authorNiles, Jacquin C
dc.contributor.authorKurtis, Jonathan D
dc.date.accessioned2021-10-27T19:53:40Z
dc.date.available2021-10-27T19:53:40Z
dc.date.issued2021-09-06
dc.identifier.urihttps://hdl.handle.net/1721.1/133588
dc.description.abstract<jats:p>We previously identified a Plasmodium falciparum (Pf) protein of unknown function encoded by a single-copy gene, PF3D7_1134300, as a target of antibodies in plasma of Tanzanian children in a whole-proteome differential screen. Here we characterize this protein as a blood-stage antigen that localizes to the surface membranes of both parasitized erythrocytes and merozoites, hence its designation as Pf erythrocyte membrane and merozoite antigen 1 (PfEMMA1). Mouse anti-PfEMMA1 antisera and affinity-purified human anti-PfEMMA1 antibodies inhibited growth of P. falciparum strains by up to 68% in growth inhibition assays. Following challenge with uniformly fatal Plasmodium berghei (Pb) ANKA, up to 40% of mice immunized with recombinant PbEMMA1 self-cured, and median survival of lethally infected mice was up to 2.6-fold longer than controls (21 vs. 8 d, P = 0.005). Furthermore, high levels of naturally acquired human anti-PfEMMA1 antibodies were associated with a 46% decrease in parasitemia over 2.5 yr of follow-up of Tanzanian children. Together, these findings suggest that antibodies to PfEMMA1 mediate protection against malaria.</jats:p>en_US
dc.language.isoen
dc.publisherRockefeller University Pressen_US
dc.relation.isversionof10.1084/jem.20200170en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceRockefeller University Pressen_US
dc.titleA newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodiesen_US
dc.typeArticleen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineering
dc.relation.journalJournal of Experimental Medicineen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-09-10T13:32:45Z
dspace.orderedauthorsMichelow, IC; Park, S; Tsai, S-W; Rayta, B; Pasaje, CFA; Nelson, S; Early, AM; Frosch, AP; Ayodo, G; Raj, DK; Nixon, CE; Nixon, CP; Pond-Tor, S; Friedman, JF; Fried, M; Duffy, PE; Le Roch, KG; Niles, JC; Kurtis, JDen_US
dspace.date.submission2021-09-10T13:32:48Z
mit.journal.volume218en_US
mit.journal.issue9en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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