Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

Author(s)
Acharya, Nandini; Madi, Asaf; Zhang, Huiyuan; Klapholz, Max; Escobar, Giulia; ... Show more
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Abstract
© 2020 Elsevier Inc. Acharya et al. uncover a gradient of increasing glucocorticoid signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes. This gradient regulates effector transition and development of dysfunction. Glucocorticoid is produced locally by tumor-associated monocyte-macrophage lineage cells, and presence of active glucocorticoid signaling associates with poor response to immune checkpoint blockade.
Date issued
2020
URI
https://hdl.handle.net/1721.1/133832
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT; Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology); Howard Hughes Medical Institute
Journal
Immunity
Publisher
Elsevier BV
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