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Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

dc.contributor.authorLee, Hyeseung
dc.contributor.authorFenster, Robert J
dc.contributor.authorPineda, S Sebastian
dc.contributor.authorGibbs, Whitney S
dc.contributor.authorMohammadi, Shahin
dc.contributor.authorDavila-Velderrain, Jose
dc.contributor.authorGarcia, Francisco J
dc.contributor.authorTherrien, Martine
dc.contributor.authorNovis, Hailey S
dc.contributor.authorGao, Fan
dc.contributor.authorWilkinson, Hilary
dc.contributor.authorVogt, Thomas
dc.contributor.authorKellis, Manolis
dc.contributor.authorLaVoie, Matthew J
dc.contributor.authorHeiman, Myriam
dc.date.accessioned2021-10-27T19:56:53Z
dc.date.available2021-10-27T19:56:53Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/1721.1/133834
dc.description.abstractLee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vulnerability in HD.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/J.NEURON.2020.06.021en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleCell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activationen_US
dc.typeArticleen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.contributor.departmentPicower Institute for Learning and Memory
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
dc.contributor.departmentMassachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
dc.relation.journalNeuronen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-09-20T14:40:09Z
dspace.orderedauthorsLee, H; Fenster, RJ; Pineda, SS; Gibbs, WS; Mohammadi, S; Davila-Velderrain, J; Garcia, FJ; Therrien, M; Novis, HS; Gao, F; Wilkinson, H; Vogt, T; Kellis, M; LaVoie, MJ; Heiman, Men_US
dspace.date.submission2021-09-20T14:40:13Z
mit.journal.volume107en_US
mit.journal.issue5en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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