Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Author(s)
Chung, Katherine Minjee; Singh, Jaffarguriqbal; Lawres, Lauren; Dorans, Kimberly Judith; Garcia, Cathy; ... Show more
Thumbnail
DownloadAccepted version (2.669Mb)
Publisher with Creative Commons License
Terms of use
Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/
Metadata
Show full item record
Abstract
© 2020 Elsevier Inc. Obesity is an intrinsic driver of PDAC in mice, leading to a remodeling of beta cells to increase CCK secretion and playing a role early in pancreatic cancer development that can be intercepted by weight loss.
Date issued
2020
URI
https://hdl.handle.net/1721.1/134176
Department
Koch Institute for Integrative Cancer Research at MIT; Howard Hughes Medical Institute
Journal
Cell
Publisher
Elsevier BV
Collections