Controlling Spatial Organization of Multiple Cell Types in Defined 3D Geometries

Author(s)
Tekin, Halil; Sanchez, Jefferson G; Landeros, Christian; Dubbin, Karen; Langer, Robert; ... Show more
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Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
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Abstract
A simple method to control spatial organizations of multiple cell types in predefined geometries by using poly(N-isopropylacrylamide)-based dynamic microwells is described. Dynamic microwells are used to pattern two different cell types in a spatially controlled manner by exploiting their shape changing properties at two different temperatures. Both spatial organization of two different cell types and control of pattern geometry are achieved with circular and square dynamic microwells. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Date issued
2012
URI
https://hdl.handle.net/1721.1/134516
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering
Journal
Advanced Materials
Publisher
Wiley
Citation
Tekin, H., et al. "Controlling Spatial Organization of Multiple Cell Types in Defined 3d Geometries." Adv Mater (2012).
Version: Author's final manuscript
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