A comparative genomics multitool for scientific discovery and conservation
dc.contributor.author | Genereux, DP | |
dc.contributor.author | Serres, A | |
dc.contributor.author | Armstrong, J | |
dc.contributor.author | Johnson, J | |
dc.contributor.author | Marinescu, VD | |
dc.contributor.author | Muren, E | |
dc.contributor.author | Juan, D | |
dc.contributor.author | Bejerano, G | |
dc.contributor.author | Casewell, NR | |
dc.contributor.author | Chemnick, LG | |
dc.contributor.author | Damas, J | |
dc.contributor.author | Di Palma, F | |
dc.contributor.author | Diekhans, M | |
dc.contributor.author | Fiddes, IT | |
dc.contributor.author | Garber, M | |
dc.contributor.author | Gladyshev, NV | |
dc.contributor.author | Goodman, L | |
dc.contributor.author | Haerty, W | |
dc.contributor.author | Houck, ML | |
dc.contributor.author | Hubley, R | |
dc.contributor.author | Kivioja, T | |
dc.contributor.author | Koepfli, KP | |
dc.contributor.author | Kuderna, LFK | |
dc.contributor.author | Lander, Eric Steven | |
dc.contributor.author | Meadows, JRS | |
dc.contributor.author | Murphy, WJ | |
dc.contributor.author | Nash, W | |
dc.contributor.author | Noh, HJ | |
dc.contributor.author | Nweeia, M | |
dc.contributor.author | Pfenning, AR | |
dc.contributor.author | Pollard, KS | |
dc.contributor.author | Ray, DA | |
dc.contributor.author | Shapiro, B | |
dc.contributor.author | Smit, AFA | |
dc.contributor.author | Springer, MS | |
dc.contributor.author | Steiner, CC | |
dc.contributor.author | Swofford, R | |
dc.contributor.author | Taipale, J | |
dc.contributor.author | Teeling, EC | |
dc.contributor.author | Turner-Maier, J | |
dc.contributor.author | Alfoldi, J | |
dc.contributor.author | Birren, B | |
dc.contributor.author | Ryder, OA | |
dc.contributor.author | Lewin, HA | |
dc.contributor.author | Paten, B | |
dc.contributor.author | Marques-Bonet, T | |
dc.contributor.author | Lindblad-Toh, K | |
dc.contributor.author | Karlsson, EK | |
dc.date.accessioned | 2022-04-14T20:12:20Z | |
dc.date.available | 2021-10-27T20:05:54Z | |
dc.date.available | 2022-04-14T20:12:20Z | |
dc.date.issued | 2020-11-12 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/134633.2 | |
dc.description.abstract | © 2020, The Author(s). The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity. | en_US |
dc.language.iso | en | |
dc.publisher | Springer Science and Business Media LLC | en_US |
dc.relation.isversionof | 10.1038/s41586-020-2876-6 | en_US |
dc.rights | Creative Commons Attribution 4.0 International license | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Nature | en_US |
dc.title | A comparative genomics multitool for scientific discovery and conservation | en_US |
dc.type | Article | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.relation.journal | Nature | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2021-07-20T17:44:07Z | |
dspace.orderedauthors | Genereux, DP; Serres, A; Armstrong, J; Johnson, J; Marinescu, VD; Murén, E; Juan, D; Bejerano, G; Casewell, NR; Chemnick, LG; Damas, J; Di Palma, F; Diekhans, M; Fiddes, IT; Garber, M; Gladyshev, VN; Goodman, L; Haerty, W; Houck, ML; Hubley, R; Kivioja, T; Koepfli, KP; Kuderna, LFK; Lander, ES; Meadows, JRS; Murphy, WJ; Nash, W; Noh, HJ; Nweeia, M; Pfenning, AR; Pollard, KS; Ray, DA; Shapiro, B; Smit, AFA; Springer, MS; Steiner, CC; Swofford, R; Taipale, J; Teeling, EC; Turner-Maier, J; Alfoldi, J; Birren, B; Ryder, OA; Lewin, HA; Paten, B; Marques-Bonet, T; Lindblad-Toh, K; Karlsson, EK | en_US |
dspace.date.submission | 2021-07-20T17:44:09Z | |
mit.journal.volume | 587 | en_US |
mit.journal.issue | 7833 | en_US |
mit.license | PUBLISHER_CC | |
mit.metadata.status | Publication Information Needed | en_US |