SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock

Author(s)
Liebelt, Frauke; Sebastian, Rebecca M; Moore, Christopher L; Mulder, Monique PC; Ovaa, Huib; ... Show more
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Abstract
© 2018 The Author(s) Functional consequences of SUMO2/3 conjugation during proteotoxic stress remain unclear. Liebelt et al. show that SUMO2/3 acts synergistically with the proteostasis network to reduce aggregation during acute heat shock and facilitate target degradation by the proteasome during stress recovery. SUMO2/3, therefore, acts as a first protective response to proteotoxic stress.
Date issued
2019
URI
https://hdl.handle.net/1721.1/135158
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Cell Reports
Publisher
Elsevier BV
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