SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock
Author(s)Liebelt, Frauke; Sebastian, Rebecca M; Moore, Christopher L; Mulder, Monique PC; Ovaa, Huib; Shoulders, Matthew D; Vertegaal, Alfred CO; ... Show more Show less
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© 2018 The Author(s) Functional consequences of SUMO2/3 conjugation during proteotoxic stress remain unclear. Liebelt et al. show that SUMO2/3 acts synergistically with the proteostasis network to reduce aggregation during acute heat shock and facilitate target degradation by the proteasome during stress recovery. SUMO2/3, therefore, acts as a first protective response to proteotoxic stress.