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Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

dc.contributor.authorSieberts, Solveig K.
dc.contributor.authorPerumal, Thanneer M.
dc.contributor.authorCarrasquillo, Minerva M.
dc.contributor.authorAllen, Mariet
dc.contributor.authorReddy, Joseph S.
dc.contributor.authorHoffman, Gabriel E.
dc.contributor.authorDang, Kristen K.
dc.contributor.authorCalley, John
dc.contributor.authorEbert, Philip J.
dc.contributor.authorEddy, James
dc.contributor.authorWang, Xue
dc.contributor.authorGreenwood, Anna K.
dc.contributor.authorMostafavi, Sara
dc.contributor.authorAkbarian, Schahram
dc.contributor.authorBendl, Jaroslav
dc.contributor.authorBreen, Michael S.
dc.contributor.authorBrennand, Kristen
dc.contributor.authorBrown, Leanne
dc.contributor.authorBrowne, Andrew
dc.contributor.authorBuxbaum, Joseph D.
dc.contributor.authorCharney, Alexander
dc.contributor.authorChess, Andrew
dc.contributor.authorCouto, Lizette
dc.contributor.authorCrawford, Greg
dc.contributor.authorDevillers, Olivia
dc.contributor.authorDevlin, Bernie
dc.contributor.authorDobbyn, Amanda
dc.contributor.authorDomenici, Enrico
dc.contributor.authorFilosi, Michele
dc.contributor.authorFlatow, Elie
dc.contributor.authorFrancoeur, Nancy
dc.contributor.authorFullard, John
dc.contributor.authorGil, Sergio Espeso
dc.contributor.authorGirdhar, Kiran
dc.contributor.authorGulyás-Kovács, Attila
dc.contributor.authorGur, Raquel
dc.contributor.authorHahn, Chang-Gyu
dc.contributor.authorHaroutunian, Vahram
dc.contributor.authorHauberg, Mads Engel
dc.contributor.authorHuckins, Laura
dc.contributor.authorJacobov, Rivky
dc.contributor.authorJiang, Yan
dc.contributor.authorJohnson, Jessica S.
dc.contributor.authorKassim, Bibi
dc.contributor.authorKim, Yungil
dc.contributor.authorKlei, Lambertus
dc.contributor.authorKramer, Robin
dc.contributor.authorLauria, Mario
dc.contributor.authorLehner, Thomas
dc.contributor.authorLewis, David A.
dc.contributor.authorLipska, Barbara K.
dc.contributor.authorMontgomery, Kelsey
dc.contributor.authorPark, Royce
dc.contributor.authorRosenbluh, Chaggai
dc.contributor.authorRoussos, Panagiotis
dc.contributor.authorRuderfer, Douglas M.
dc.contributor.authorSenthil, Geetha
dc.contributor.authorShah, Hardik R.
dc.contributor.authorSloofman, Laura
dc.contributor.authorSong, Lingyun
dc.contributor.authorStahl, Eli
dc.contributor.authorSullivan, Patrick
dc.contributor.authorVisintainer, Roberto
dc.contributor.authorWang, Jiebiao
dc.contributor.authorWang, Ying-Chih
dc.contributor.authorWiseman, Jennifer
dc.contributor.authorXia, Eva
dc.contributor.authorZhang, Wen
dc.contributor.authorZharovsky, Elizabeth
dc.contributor.authorAddis, Laura
dc.contributor.authorAddo, Sadiya N.
dc.contributor.authorAirey, David Charles
dc.contributor.authorArnold, Matthias
dc.contributor.authorBennett, David A.
dc.contributor.authorBi, Yingtao
dc.contributor.authorBiber, Knut
dc.contributor.authorBlach, Colette
dc.contributor.authorBradhsaw, Elizabeth
dc.contributor.authorBrennan, Paul
dc.contributor.authorCanet-Aviles, Rosa
dc.contributor.authorCao, Sherry
dc.contributor.authorCavalla, Anna
dc.contributor.authorChae, Yooree
dc.contributor.authorChen, William W.
dc.contributor.authorCheng, Jie
dc.contributor.authorCollier, David Andrew
dc.contributor.authorDage, Jeffrey L.
dc.contributor.authorDammer, Eric B.
dc.contributor.authorDavis, Justin Wade
dc.contributor.authorDavis, John
dc.contributor.authorDrake, Derek
dc.contributor.authorDuong, Duc
dc.contributor.authorEastwood, Brian J.
dc.contributor.authorEhrlich, Michelle
dc.contributor.authorEllingson, Benjamin
dc.contributor.authorEngelmann, Brett W.
dc.contributor.authorEsmaeelinieh, Sahar
dc.contributor.authorFelsky, Daniel
dc.contributor.authorFunk, Cory
dc.contributor.authorGaiteri, Chris
dc.contributor.authorGandy, Samuel
dc.contributor.authorGao, Fan
dc.contributor.authorGileadi, Opher
dc.contributor.authorGolde, Todd
dc.contributor.authorGrosskurth, Shaun E.
dc.contributor.authorGupta, Rishi R.
dc.contributor.authorGutteridge, Alex X.
dc.contributor.authorHaroutunian, Vahram
dc.contributor.authorHooli, Basavaraj
dc.contributor.authorHumphryes-Kirilov, Neil
dc.contributor.authorIijima, Koichi
dc.contributor.authorJames, Corey
dc.contributor.authorJung, Paul M.
dc.contributor.authorKaddurah-Daouk, Rima
dc.contributor.authorKastenmuller, Gabi
dc.contributor.authorKlein, Hans-Ulrich
dc.contributor.authorKummer, Markus
dc.contributor.authorLacor, Pascale N.
dc.contributor.authorLah, James
dc.contributor.authorLaing, Emma
dc.contributor.authorLevey, Allan
dc.contributor.authorLi, Yupeng
dc.contributor.authorLipsky, Samantha
dc.contributor.authorLiu, Yushi
dc.contributor.authorLiu, Jimmy
dc.contributor.authorLiu, Zhandong
dc.contributor.authorLouie, Gregory
dc.contributor.authorLu, Tao
dc.contributor.authorMa, Yiyi
dc.contributor.authorMatsuoka, Yasuji Y.
dc.contributor.authorMenon, Vilas
dc.contributor.authorMiller, Bradley
dc.contributor.authorMisko, Thomas P.
dc.contributor.authorMollon, Jennifer E.
dc.contributor.authorMontgomery, Kelsey
dc.contributor.authorMukherjee, Sumit
dc.contributor.authorNoggle, Scott
dc.contributor.authorPao, Ping-Chieh
dc.contributor.authorPearce, Tracy Young
dc.contributor.authorPearson, Neil
dc.contributor.authorPenny, Michelle
dc.contributor.authorPetyuk, Vladislav A.
dc.contributor.authorPrice, Nathan
dc.contributor.authorQuarless, Danjuma X.
dc.contributor.authorRavikumar, Brinda
dc.contributor.authorRied, Janina S.
dc.contributor.authorRuble, Cara Lee Ann
dc.contributor.authorRunz, Heiko
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorSchadt, Eric
dc.contributor.authorScherschel, James E.
dc.contributor.authorSeyfried, Nicholas
dc.contributor.authorShulman, Joshua M.
dc.contributor.authorSnyder, Phil
dc.contributor.authorSoares, Holly
dc.contributor.authorSrivastava, Gyan P.
dc.contributor.authorStockmann, Henning
dc.contributor.authorTaga, Mariko
dc.contributor.authorTasaki, Shinya
dc.contributor.authorTenenbaum, Jessie
dc.contributor.authorTsai, Li-Huei
dc.contributor.authorVasanthakumar, Aparna
dc.contributor.authorWachter, Astrid
dc.contributor.authorWang, Yaming
dc.contributor.authorWang, Hong
dc.contributor.authorWang, Minghui
dc.contributor.authorWhelan, Christopher D.
dc.contributor.authorWhite, Charles
dc.contributor.authorWoo, Kara H.
dc.contributor.authorWren, Paul
dc.contributor.authorWu, Jessica W.
dc.contributor.authorXi, Hualin S.
dc.contributor.authorYankner, Bruce A.
dc.contributor.authorYounkin, Steven G.
dc.contributor.authorYu, Lei
dc.contributor.authorZavodszky, Maria
dc.contributor.authorZhang, Wenling
dc.contributor.authorZhang, Guoqiang
dc.contributor.authorZhang, Bin
dc.contributor.authorZhu, Jun
dc.contributor.authorOmberg, Larsson
dc.contributor.authorPeters, Mette A.
dc.contributor.authorLogsdon, Benjamin A.
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorErtekin-Taner, Nilüfer
dc.contributor.authorMangravite, Lara M.
dc.date.accessioned2022-03-21T15:00:41Z
dc.date.available2021-10-27T20:22:50Z
dc.date.available2022-03-21T15:00:41Z
dc.date.issued2020-10
dc.date.submitted2019-05
dc.identifier.issn2052-4463
dc.identifier.urihttps://hdl.handle.net/1721.1/135294.2
dc.description.abstract© 2020, The Author(s). The availability of high-quality RNA-sequencing and genotyping data of post-mortem brain collections from consortia such as CommonMind Consortium (CMC) and the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Consortium enable the generation of a large-scale brain cis-eQTL meta-analysis. Here we generate cerebral cortical eQTL from 1433 samples available from four cohorts (identifying >4.1 million significant eQTL for >18,000 genes), as well as cerebellar eQTL from 261 samples (identifying 874,836 significant eQTL for >10,000 genes). We find substantially improved power in the meta-analysis over individual cohort analyses, particularly in comparison to the Genotype-Tissue Expression (GTEx) Project eQTL. Additionally, we observed differences in eQTL patterns between cerebral and cerebellar brain regions. We provide these brain eQTL as a resource for use by the research community. As a proof of principle for their utility, we apply a colocalization analysis to identify genes underlying the GWAS association peaks for schizophrenia and identify a potentially novel gene colocalization with lncRNA RP11-677M14.2 (posterior probability of colocalization 0.975).en_US
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/s41597-020-00642-8en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceScientific Reportsen_US
dc.titleLarge eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regionsen_US
dc.typeArticleen_US
dc.contributor.departmentPicower Institute for Learning and Memory
dc.relation.journalScientific Dataen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-03-18T15:07:34Z
dspace.orderedauthorsSieberts, SK; Perumal, TM; Carrasquillo, MM; Allen, M; Reddy, JS; Hoffman, GE; Dang, KK; Calley, J; Ebert, PJ; Eddy, J; Wang, X; Greenwood, AK; Mostafavi, S; Akbarian, S; Bendl, J; Breen, MS; Brennand, K; Brown, L; Browne, A; Buxbaum, JD; Charney, A; Chess, A; Couto, L; Crawford, G; Devillers, O; Devlin, B; Dobbyn, A; Domenici, E; Filosi, M; Flatow, E; Francoeur, N; Fullard, J; Gil, SE; Girdhar, K; Gulyás-Kovács, A; Gur, R; Hahn, CG; Haroutunian, V; Hauberg, ME; Huckins, L; Jacobov, R; Jiang, Y; Johnson, JS; Kassim, B; Kim, Y; Klei, L; Kramer, R; Lauria, M; Lehner, T; Lewis, DA; Lipska, BK; Montgomery, K; Park, R; Rosenbluh, C; Roussos, P; Ruderfer, DM; Senthil, G; Shah, HR; Sloofman, L; Song, L; Stahl, E; Sullivan, P; Visintainer, R; Wang, J; Wang, YC; Wiseman, J; Xia, E; Zhang, W; Zharovsky, E; Addis, L; Addo, SN; Airey, DC; Arnold, M; Bennett, DA; Bi, Y; Biber, K; Blach, C; Bradhsaw, E; Brennan, P; Canet-Aviles, R; Cao, S; Cavalla, A; Chae, Y; Chen, WW; Cheng, J; Collier, DA; Dage, JL; Dammer, EB; Davis, JW; Davis, J; Drake, D; Duong, D; Eastwood, BJ; Ehrlich, M; Ellingson, B; Engelmann, BW; Esmaeelinieh, S; Felsky, D; Funk, C; Gaiteri, Cen_US
dspace.date.submission2021-03-18T15:07:35Z
mit.journal.volume7en_US
mit.journal.issue1en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work Neededen_US


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