Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Author(s)
Ku, Taeyun; Guan, Webster; Evans, Nicholas B; Sohn, Chang Ho; Albanese, Alexandre; ... Show more
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Abstract
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.
Date issued
2020
URI
https://hdl.handle.net/1721.1/135336
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Picower Institute for Learning and Memory; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal
Nature Methods
Publisher
Springer Science and Business Media LLC
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