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dc.contributor.authorHuda, Rafiq
dc.contributor.authorSipe, Grayson O
dc.contributor.authorBreton-Provencher, Vincent
dc.contributor.authorCruz, K Guadalupe
dc.contributor.authorPho, Gerald N
dc.contributor.authorAdam, Elie
dc.contributor.authorGunter, Liadan M
dc.contributor.authorSullins, Austin
dc.contributor.authorWickersham, Ian R
dc.contributor.authorSur, Mriganka
dc.date.accessioned2021-10-27T20:23:48Z
dc.date.available2021-10-27T20:23:48Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/1721.1/135518
dc.description.abstract© 2020, The Author(s). Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined the sensorimotor function of anatomically distinct outputs from a subdivision of the mouse PFC, the anterior cingulate cortex (ACC). Using a visually guided two-choice behavioral paradigm with multiple cue-response mappings, we dissociated the sensory and motor response components of sensorimotor control. Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate specific motor responses. Importantly, ACC outputs exert control by reducing the innate response bias of the superior colliculus. In contrast, ACC outputs to the visual cortex facilitate sensory processing of visual cues. Our results ascribe motor and sensory roles to ACC projections to the superior colliculus and the visual cortex and demonstrate for the first time a circuit motif for PFC function wherein anatomically non-overlapping output pathways coordinate complementary but distinct aspects of visual sensorimotor behavior.
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.isversionof10.1038/s41467-020-19772-z
dc.rightsCreative Commons Attribution 4.0 International license
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceNature
dc.titleDistinct prefrontal top-down circuits differentially modulate sensorimotor behavior
dc.typeArticle
dc.contributor.departmentPicower Institute for Learning and Memory
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.contributor.departmentMcGovern Institute for Brain Research at MIT
dc.relation.journalNature Communications
dc.eprint.versionFinal published version
dc.type.urihttp://purl.org/eprint/type/JournalArticle
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.date.updated2021-03-18T14:48:50Z
dspace.orderedauthorsHuda, R; Sipe, GO; Breton-Provencher, V; Cruz, KG; Pho, GN; Adam, E; Gunter, LM; Sullins, A; Wickersham, IR; Sur, M
dspace.date.submission2021-03-18T14:48:53Z
mit.journal.volume11
mit.journal.issue1
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Needed


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