Leveraging Immunopeptidomics To Study and Combat Infectious Disease

Author(s)
Leddy, Owen K; White, Forest M; Bryson, Bryan D
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Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/
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Abstract
<jats:p>T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines.</jats:p>
Date issued
2021-08-31
URI
https://hdl.handle.net/1721.1/135583
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Koch Institute for Integrative Cancer Research at MIT; Ragon Institute of MGH, MIT and Harvard; Center for Precision Cancer Medicine
Journal
mSystems
Publisher
American Society for Microbiology
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