Show simple item record

dc.contributor.authorStout, Jeffrey Neil
dc.contributor.authorAdalsteinsson, Elfar
dc.contributor.authorRosen, Bruce R
dc.contributor.authorBolar, Divya Sanam
dc.date.accessioned2022-04-29T16:51:41Z
dc.date.available2021-10-27T20:34:55Z
dc.date.available2022-04-29T16:51:41Z
dc.date.issued2018
dc.identifier.issn1522-2594
dc.identifier.urihttps://hdl.handle.net/1721.1/136336.2
dc.description.abstract© 2017 International Society for Magnetic Resonance in Medicine Purpose: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) is a recent technique that measures voxel-wise oxygen extraction fraction (OEF) but suffers from long scan times, limiting its application. We implemented multiecho QUIXOTIC dubbed turbo QUIXOTIC (tQUIXOTIC) that reduces scan time eightfold and then applied it in functional MRI. Methods: tQUIXOTIC utilizes a novel turbo gradient spin echo readout enabling measurement of venular blood transverse relaxation rate in a single tag-control acquisition. Using tQUIXOTIC, we estimated cortical gray matter (GM) OEF, created voxel-by-voxel GM OEF maps, and quantified changes in visual cortex OEF during a blocked design flashing checkerboard visual stimulus. Contamination from cerebrospinal fluid partial volume averaging was estimated and corrected. Results: The average cortical GM OEF was estimated as 0.38 ± 0.06 (n = 8) using a 3.4-min acquisition. The average OEF in the visual cortex was estimated as 0.43 ± 0.04 at baseline and 0.35 ± 0.05 during activation, with an average %ΔOEF of −20%. These values are consistent with those of past studies. Conclusion: tQUIXOTIC successfully estimated cortical GM OEF in clinical scan times and detected changes in OEF during blocked design visual stimulation. tQUIXOTIC will be useful to monitor regional OEF clinically and in blocked design or event-related functional MRI experiments. Magn Reson Med 79:2713–2723, 2018. © 2017 International Society for Magnetic Resonance in Medicine.en_US
dc.description.sponsorshipNIH Blueprint for Neuroscience Research (T90DA022759/R90DA023427)en_US
dc.description.sponsorshipNIBIB-NIH (5T32EB1680)en_US
dc.language.isoen
dc.publisherWileyen_US
dc.relation.isversionofhttps://dx.doi.org/10.1002/MRM.26947en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleFunctional oxygen extraction fraction (OEF) imaging with turbo gradient spin echo QUIXOTIC (Turbo QUIXOTIC)en_US
dc.typeArticleen_US
dc.contributor.departmentHarvard-MIT Program in Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.relation.journalMagnetic Resonance in Medicineen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-05-01T16:20:40Z
dspace.orderedauthorsStout, JN; Adalsteinsson, E; Rosen, BR; Bolar, DSen_US
dspace.date.submission2019-05-01T16:20:41Z
mit.journal.volume79en_US
mit.journal.issue5en_US
mit.metadata.statusPublication Information Neededen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

VersionItemDateSummary

*Selected version