Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

Author(s)
Yehl, Kevin; Lemire, Sébastien; Yang, Andrew C; Ando, Hiroki; Mimee, Mark; ... Show more
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Abstract
© 2019 Elsevier Inc. Bacteriophage libraries containing millions of variants of phage tail fiber motifs on a common structural scaffold give rise to infectious phages with expanded or altered host ranges, which may be useful for phage therapy efforts.
Date issued
2019
URI
https://hdl.handle.net/1721.1/136451
Department
Massachusetts Institute of Technology. Synthetic Biology Center; Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics; Massachusetts Institute of Technology. Research Laboratory of Electronics; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Cell
Publisher
Elsevier BV
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