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dc.contributor.authorSarkar, Sumantra
dc.contributor.authorEngland, Jeremy L.
dc.date.accessioned2021-11-01T14:37:32Z
dc.date.available2021-11-01T14:37:32Z
dc.date.issued2019-08-26
dc.identifier.urihttps://hdl.handle.net/1721.1/136943
dc.description.abstractA “self-replicator” is usually understood to be an object of definite form that promotes the conversion of materials in its environment into a nearly identical copy of itself. The challenge of engineering novel, micro- or nanoscale self-replicators has attracted keen interest in recent years, both because exponential amplification is an attractive method for generating high yields of specific products and, also, because self-reproducing entities have the potential to be optimized or adapted through rounds of iterative selection. Substantial steps forward have been achieved both in the engineering of particular self-replicating molecules and in the characterization of the physical basis for possible mechanisms of self-replication. At present, however, there is a need for a theoretical treatment of what physical conditions are most conducive to the emergence of novel self-replicating structures from a reservoir of building blocks on a desired time scale. Here we report progress in addressing this need. By analyzing the kinetics of a toy chemical model, we demonstrate that the emergence of self-replication can be controlled by coarse, tunable features of the chemical system, such as the fraction of fast reactions and the width of the rate constant distribution. We also find that the typical mechanism is dominated by the cooperation of multiple interconnected reaction cycles as opposed to a single isolated cycle. The quantitative treatment presented here may prove useful for designing novel self-replicating chemical systems.en_US
dc.publisherAmerican Physical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1103/PhysRevE.100.022414en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceAmerican Physical Societyen_US
dc.titleDesign of conditions for self-replicationen_US
dc.typeArticleen_US
dc.identifier.citationPhys. Rev. E 100, 022414 (2019)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physics
dc.identifier.mitlicensePUBLISHER_POLICY
dc.identifier.mitlicensePUBLISHER_POLICY
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-08-29T21:01:51Z
dc.language.rfc3066en
dc.rights.holderAmerican Physical Society
dspace.date.submission2019-08-29T21:01:51Z
mit.metadata.statusAuthority Work and Publication Information Needed


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