dc.contributor.author | Rajalingham, Rishi | |
dc.contributor.author | Sorenson, Michael | |
dc.contributor.author | Azadi, Reza | |
dc.contributor.author | Bohn, Simon | |
dc.contributor.author | DiCarlo, James J | |
dc.contributor.author | Afraz, Arash | |
dc.date.accessioned | 2021-11-22T19:47:49Z | |
dc.date.available | 2021-11-22T19:47:49Z | |
dc.date.issued | 2021-09 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/138202 | |
dc.description.abstract | Optogenetic methods have been widely used in rodent brains, but remain relatively under-developed for nonhuman primates such as rhesus macaques, an animal model with a large brain expressing sophisticated sensory, motor and cognitive behaviors. To address challenges in behavioral optogenetics in large brains, we developed Opto-Array, a chronically implantable array of light-emitting diodes for high-throughput optogenetic perturbation. We demonstrated that optogenetic silencing in the macaque primary visual cortex with the help of the Opto-Array results in reliable retinotopic visual deficits in a luminance discrimination task. We separately confirmed that Opto-Array illumination results in local neural silencing, and that behavioral effects are not due to tissue heating. These results demonstrate the effectiveness of the Opto-Array for behavioral optogenetic applications in large brains. | en_US |
dc.language.iso | en | |
dc.publisher | Springer Science and Business Media LLC | en_US |
dc.relation.isversionof | 10.1038/s41592-021-01238-9 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | bioRxiv | en_US |
dc.title | Chronically implantable LED arrays for behavioral optogenetics in primates | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Rajalingham, Rishi, Sorenson, Michael, Azadi, Reza, Bohn, Simon, DiCarlo, James J et al. 2021. "Chronically implantable LED arrays for behavioral optogenetics in primates." Nature Methods, 18 (9). | |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | |
dc.contributor.department | McGovern Institute for Brain Research at MIT | |
dc.contributor.department | Center for Brains, Minds, and Machines | |
dc.relation.journal | Nature Methods | en_US |
dc.eprint.version | Original manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/NonPeerReviewed | en_US |
dc.date.updated | 2021-11-22T19:43:38Z | |
dspace.orderedauthors | Rajalingham, R; Sorenson, M; Azadi, R; Bohn, S; DiCarlo, JJ; Afraz, A | en_US |
dspace.date.submission | 2021-11-22T19:43:40Z | |
mit.journal.volume | 18 | en_US |
mit.journal.issue | 9 | en_US |
mit.license | PUBLISHER_POLICY | |
mit.metadata.status | Authority Work and Publication Information Needed | en_US |