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dc.contributor.authorRajalingham, Rishi
dc.contributor.authorSorenson, Michael
dc.contributor.authorAzadi, Reza
dc.contributor.authorBohn, Simon
dc.contributor.authorDiCarlo, James J
dc.contributor.authorAfraz, Arash
dc.date.accessioned2021-11-22T19:47:49Z
dc.date.available2021-11-22T19:47:49Z
dc.date.issued2021-09
dc.identifier.urihttps://hdl.handle.net/1721.1/138202
dc.description.abstractOptogenetic methods have been widely used in rodent brains, but remain relatively under-developed for nonhuman primates such as rhesus macaques, an animal model with a large brain expressing sophisticated sensory, motor and cognitive behaviors. To address challenges in behavioral optogenetics in large brains, we developed Opto-Array, a chronically implantable array of light-emitting diodes for high-throughput optogenetic perturbation. We demonstrated that optogenetic silencing in the macaque primary visual cortex with the help of the Opto-Array results in reliable retinotopic visual deficits in a luminance discrimination task. We separately confirmed that Opto-Array illumination results in local neural silencing, and that behavioral effects are not due to tissue heating. These results demonstrate the effectiveness of the Opto-Array for behavioral optogenetic applications in large brains.en_US
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionof10.1038/s41592-021-01238-9en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcebioRxiven_US
dc.titleChronically implantable LED arrays for behavioral optogenetics in primatesen_US
dc.typeArticleen_US
dc.identifier.citationRajalingham, Rishi, Sorenson, Michael, Azadi, Reza, Bohn, Simon, DiCarlo, James J et al. 2021. "Chronically implantable LED arrays for behavioral optogenetics in primates." Nature Methods, 18 (9).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.contributor.departmentMcGovern Institute for Brain Research at MIT
dc.contributor.departmentCenter for Brains, Minds, and Machines
dc.relation.journalNature Methodsen_US
dc.eprint.versionOriginal manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/NonPeerRevieweden_US
dc.date.updated2021-11-22T19:43:38Z
dspace.orderedauthorsRajalingham, R; Sorenson, M; Azadi, R; Bohn, S; DiCarlo, JJ; Afraz, Aen_US
dspace.date.submission2021-11-22T19:43:40Z
mit.journal.volume18en_US
mit.journal.issue9en_US
mit.licensePUBLISHER_POLICY
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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