Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model

Author(s)
Friedman, Alexander; Hueske, Emily; Drammis, Sabrina M; Toro Arana, Sebastian E; Nelson, Erik D; ... Show more
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Abstract
© 2020 Elsevier Inc. Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders.
Date issued
2020
URI
https://hdl.handle.net/1721.1/138257
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; McGovern Institute for Brain Research at MIT; Ragon Institute of MGH, MIT and Harvard
Journal
Cell
Publisher
Elsevier BV
Citation
Friedman, Alexander, Hueske, Emily, Drammis, Sabrina M, Toro Arana, Sebastian E, Nelson, Erik D et al. 2020. "Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model." Cell, 183 (4).
Version: Author's final manuscript
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