Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis

Author(s)
Roussarie, Jean-Pierre; Yao, Vicky; Rodriguez-Rodriguez, Patricia; Oughtred, Rose; Rust, Jennifer; ... Show more
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Abstract
© 2020 The Authors Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.
Date issued
2020
URI
https://hdl.handle.net/1721.1/138269
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Journal
Neuron
Publisher
Elsevier BV
Citation
Roussarie, Jean-Pierre, Yao, Vicky, Rodriguez-Rodriguez, Patricia, Oughtred, Rose, Rust, Jennifer et al. 2020. "Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis." Neuron, 107 (5).
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