Interfacial load monitoring and failure detection in total joint replacements via piezoresistive bone cement and electrical impedance tomography

Abstract

© 2020 IOP Publishing Ltd. Aseptic loosening, or loss of implant fixation, is a common complication following total joint replacement. Revision surgeries cost the healthcare system over $8 billion annually in the United States. Despite the prevalence of aseptic loosening, timely and accurate detection remains a challenge because traditional imaging modalities, such as plain radiographs, struggle to reliably detect the early stages of implant loosening. Motivated by this challenge, we present a novel approach for in vivo monitoring and failure detection of cemented joint replacements. Poly(methyl methacrylate) (PMMA) bone cement is modified with low volume fractions of chopped carbon fiber (CF) to impart piezoresistive-based self-sensing. Electrical impedance tomography (EIT) is then used to detect and monitor load-induced deformation and fracture of CF/PMMA in a phantom tank. We therefore show that EIT indeed is able to detect loading force on a prosthetic surrogate, distinguish between increasing load magnitudes, detect failure of implant fixation, and even distinguish between cement cracking and cement de-bonding without direct contact to the surrogate. Because EIT is a low-cost, physiologically benign, and potentially real-time imaging modality, the feasibility study herein presented could positively impact orthopedic researchers by providing, via in vivo monitoring, insight into the factors that initiate aseptic loosening.