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dc.contributor.authorSingh, Manisha
dc.contributor.authorPark, Clara
dc.contributor.authorRoche, Ellen
dc.date.accessioned2022-01-12T20:16:10Z
dc.date.available2022-01-12T19:12:21Z
dc.date.available2022-01-12T20:16:10Z
dc.date.issued2022-01-06
dc.identifier.issn2296-4185
dc.identifier.urihttps://hdl.handle.net/1721.1/138902.2
dc.description.abstractMechanical or biological aortic valves are incorporated in physical cardiac simulators for surgical training, educational purposes, and device testing. They suffer from limitations including either a lack of anatomical and biomechanical accuracy or a short lifespan, hence limiting the authentic hands-on learning experience. Medical schools utilize hearts from human cadavers for teaching and research, but these formaldehyde-fixed aortic valves contort and stiffen relative to native valves. Here, we compare a panel of different chemical treatment methods on explanted porcine aortic valves and evaluate the microscopic and macroscopic features of each treatment with a primary focus on mechanical function. A surfactant-based decellularization method after formaldehyde fixation is shown to have mechanical properties close to those of the native aortic valve. Valves treated in this method were integrated into a custom-built left heart cardiac simulator to test their hemodynamic performance. This decellularization, post-fixation technique produced aortic valves which have ultimate stress and elastic modulus in the range of the native leaflets. Decellularization of fixed valves reduced the valvular regurgitation by 60% compared to formaldehyde-fixed valves. This fixation method has implications for scenarios where the dynamic function of preserved valves is required, such as in surgical trainers or device test rigs.en_US
dc.description.sponsorshipNational Science Foundation (Award 1847541)en_US
dc.publisherFrontiers Media SAen_US
dc.relation.isversionof10.3389/fbioe.2021.803183en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceFrontiersen_US
dc.titleDecellularization Following Fixation of Explanted Aortic Valves as a Strategy for Preserving Native Mechanical Properties and Functionen_US
dc.typeArticleen_US
dc.identifier.citationSingh, Manisha, Park, Clara and Roche, Ellen T. 2022. "Decellularization Following Fixation of Explanted Aortic Valves as a Strategy for Preserving Native Mechanical Properties and Function." 9.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2022-01-12T19:00:18Z
mit.journal.volume9en_US
mit.licensePUBLISHER_CC
mit.metadata.statusPublication Information Neededen_US


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