dc.contributor.author | Singh, Manisha | |
dc.contributor.author | Park, Clara | |
dc.contributor.author | Roche, Ellen | |
dc.date.accessioned | 2022-01-12T20:16:10Z | |
dc.date.available | 2022-01-12T19:12:21Z | |
dc.date.available | 2022-01-12T20:16:10Z | |
dc.date.issued | 2022-01-06 | |
dc.identifier.issn | 2296-4185 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/138902.2 | |
dc.description.abstract | Mechanical or biological aortic valves are incorporated in physical cardiac simulators for surgical training, educational purposes, and device testing. They suffer from limitations including either a lack of anatomical and biomechanical accuracy or a short lifespan, hence limiting the authentic hands-on learning experience. Medical schools utilize hearts from human cadavers for teaching and research, but these formaldehyde-fixed aortic valves contort and stiffen relative to native valves. Here, we compare a panel of different chemical treatment methods on explanted porcine aortic valves and evaluate the microscopic and macroscopic features of each treatment with a primary focus on mechanical function. A surfactant-based decellularization method after formaldehyde fixation is shown to have mechanical properties close to those of the native aortic valve. Valves treated in this method were integrated into a custom-built left heart cardiac simulator to test their hemodynamic performance. This decellularization, post-fixation technique produced aortic valves which have ultimate stress and elastic modulus in the range of the native leaflets. Decellularization of fixed valves reduced the valvular regurgitation by 60% compared to formaldehyde-fixed valves. This fixation method has implications for scenarios where the dynamic function of preserved valves is required, such as in surgical trainers or device test rigs. | en_US |
dc.description.sponsorship | National Science Foundation (Award 1847541) | en_US |
dc.publisher | Frontiers Media SA | en_US |
dc.relation.isversionof | 10.3389/fbioe.2021.803183 | en_US |
dc.rights | Creative Commons Attribution 4.0 International license | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Frontiers | en_US |
dc.title | Decellularization Following Fixation of Explanted Aortic Valves as a Strategy for Preserving Native Mechanical Properties and Function | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Singh, Manisha, Park, Clara and Roche, Ellen T. 2022. "Decellularization Following Fixation of Explanted Aortic Valves as a Strategy for Preserving Native Mechanical Properties and Function." 9. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.date.submission | 2022-01-12T19:00:18Z | |
mit.journal.volume | 9 | en_US |
mit.license | PUBLISHER_CC | |
mit.metadata.status | Publication Information Needed | en_US |