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A Dual CuH- and Pd-Catalyzed Stereoselective Synthesis of Highly Substituted 1,3-Dienes
| dc.contributor.author | Hou, Chuan-Jin | |
| dc.contributor.author | Schuppe, Alexander W | |
| dc.contributor.author | Knippel, James Levi | |
| dc.contributor.author | Ni, Anton Z | |
| dc.contributor.author | Buchwald, Stephen L | |
| dc.date.accessioned | 2022-02-14T19:11:10Z | |
| dc.date.available | 2022-02-14T19:11:10Z | |
| dc.date.issued | 2021-11-19 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/140334 | |
| dc.description.abstract | Conjugated dienes are versatile building blocks and prevalent substructures in synthetic chemistry. Herein, we report a method for the stereoselective hydroalkenylation of alkynes, utilizing readily available enol triflates. We leveraged an in situ-generated and geometrically pure vinyl-Cu(I) species to form the Z,Z- or Z,E-1,3-dienes in excellent stereoselectivity and yield. This approach allowed for the synthesis of highly substituted Z-dienes, including pentasubstituted 1,3-dienes, which are difficult to prepare by existing approaches. | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | 10.1021/acs.orglett.1c03324 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | chemRxiv | en_US |
| dc.title | A Dual CuH- and Pd-Catalyzed Stereoselective Synthesis of Highly Substituted 1,3-Dienes | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Hou, Chuan-Jin, Schuppe, Alexander W, Knippel, James Levi, Ni, Anton Z and Buchwald, Stephen L. 2021. "A Dual CuH- and Pd-Catalyzed Stereoselective Synthesis of Highly Substituted 1,3-Dienes." Organic Letters, 23 (22). | |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Original manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/NonPeerReviewed | en_US |
| dc.date.updated | 2022-02-14T19:05:18Z | |
| dspace.orderedauthors | Hou, C-J; Schuppe, AW; Knippel, JL; Ni, AZ; Buchwald, SL | en_US |
| dspace.date.submission | 2022-02-14T19:05:19Z | |
| mit.journal.volume | 23 | en_US |
| mit.journal.issue | 22 | en_US |
| mit.license | OPEN_ACCESS_POLICY | |
| mit.metadata.status | Authority Work and Publication Information Needed | en_US |
