Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta

Author(s)
de Vecchi, Adelaide; Faraci, Alessandro; Fernandes, Joao F.; Marlevi, David; Bellsham-Revell, Hannah; ... Show more
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Abstract
Abstract Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract
Date issued
2022-02-23
URI
https://hdl.handle.net/1721.1/140793
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Publisher
Springer US
Citation
de Vecchi, Adelaide, Faraci, Alessandro, Fernandes, Joao F., Marlevi, David, Bellsham-Revell, Hannah et al. 2022. "Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta."
Version: Final published version
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