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A concise route to MK-4482 (EIDD-2801) from cytidine

dc.contributor.authorVasudevan, N
dc.contributor.authorAhlqvist, Grace P
dc.contributor.authorMcGeough, Catherine P
dc.contributor.authorPaymode, Dinesh J
dc.contributor.authorCardoso, Flavio SP
dc.contributor.authorLucas, Tobias
dc.contributor.authorDietz, Jule-Phillip
dc.contributor.authorOpatz, Till
dc.contributor.authorJamison, Timothy F
dc.contributor.authorGupton, Frank B
dc.contributor.authorSnead, David R
dc.date.accessioned2022-03-09T15:25:53Z
dc.date.available2022-03-09T15:25:53Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/1721.1/141082
dc.description.abstract© The Royal Society of Chemistry. A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating groups and proceed in overall yield of 75%, a significant advancement over the reported yield of 17%. The step count is reduced from five transformations to two, and expensive uridine is replaced with the more available cytidine. This journal isen_US
dc.language.isoen
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.isversionof10.1039/D0CC05944Gen_US
dc.rightsCreative Commons Attribution NonCommercial License 3.0en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en_US
dc.sourceRoyal Society of Chemistry (RSC)en_US
dc.titleA concise route to MK-4482 (EIDD-2801) from cytidineen_US
dc.typeArticleen_US
dc.identifier.citationVasudevan, N, Ahlqvist, Grace P, McGeough, Catherine P, Paymode, Dinesh J, Cardoso, Flavio SP et al. 2020. "A concise route to MK-4482 (EIDD-2801) from cytidine." Chemical Communications, 56 (87).
dc.relation.journalChemical Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2022-03-09T15:24:03Z
dspace.orderedauthorsVasudevan, N; Ahlqvist, GP; McGeough, CP; Paymode, DJ; Cardoso, FSP; Lucas, T; Dietz, J-P; Opatz, T; Jamison, TF; Gupton, FB; Snead, DRen_US
dspace.date.submission2022-03-09T15:24:05Z
mit.journal.volume56en_US
mit.journal.issue87en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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21721.1/141082.22022-05-09T20:27:43ZPublication information verified/added.
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