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Total Synthesis of (−)-Kopsifoline A and (+)-Kopsifoline E
| dc.contributor.author | Myeong, In-Soo | |
| dc.contributor.author | Avci, Nadide Hazal | |
| dc.contributor.author | Movassaghi, Mohammad | |
| dc.date.accessioned | 2022-03-10T20:16:40Z | |
| dc.date.available | 2022-03-10T20:16:40Z | |
| dc.date.issued | 2021-12-03 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/141145 | |
| dc.description.abstract | We report the first total synthesis of (-)-kopsifoline A and (+)-kopsifoline E. Our synthetic strategy features a biogenetically inspired regioselective C17-functionalization of a versatile intermediate containing the pentacyclic core of aspidosperma alkaloids. The vinylogous urethane substructure of this intermediate affords (-)-kopsifoline D via C3-C21 bond formation under the Mitsunobu reaction conditions, while it enables selective C17-functionalization en route to (-)-kopsifoline A and (+)-kopsifoline E. | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | 10.1021/acs.orglett.1c03448 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | chemRxiv | en_US |
| dc.title | Total Synthesis of (−)-Kopsifoline A and (+)-Kopsifoline E | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Myeong, In-Soo, Avci, Nadide Hazal and Movassaghi, Mohammad. 2021. "Total Synthesis of (−)-Kopsifoline A and (+)-Kopsifoline E." Organic Letters, 23 (23). | |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Original manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/NonPeerReviewed | en_US |
| dc.date.updated | 2022-03-10T20:12:25Z | |
| dspace.orderedauthors | Myeong, I-S; Avci, NH; Movassaghi, M | en_US |
| dspace.date.submission | 2022-03-10T20:12:26Z | |
| mit.journal.volume | 23 | en_US |
| mit.journal.issue | 23 | en_US |
| mit.license | OPEN_ACCESS_POLICY | |
| mit.metadata.status | Authority Work and Publication Information Needed | en_US |
