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dc.contributor.authorSamuelsson, JG
dc.contributor.authorSundaram, P
dc.contributor.authorKhan, S
dc.contributor.authorSereno, MI
dc.contributor.authorHämäläinen, MS
dc.date.accessioned2022-03-17T15:38:51Z
dc.date.available2022-03-17T15:38:51Z
dc.date.issued2020-06-15
dc.identifier.urihttps://hdl.handle.net/1721.1/141258
dc.description.abstract© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability of MEG and EEG to detect cerebellar activity using a model that employs a high-resolution tessellation of the cerebellar cortex. The tessellation was constructed from repetitive high-field (9.4T) structural magnetic resonance imaging (MRI) of an ex vivo human cerebellum. A boundary-element forward model was then used to simulate the M/EEG signals resulting from neural activity in the cerebellar cortex. Despite significant signal cancelation due to the highly convoluted cerebellar cortex, we found that the cerebellar signal was on average only 30–60% weaker than the cortical signal. We also made detailed M/EEG sensitivity maps and found that MEG and EEG have highly complementary sensitivity distributions over the cerebellar cortex. Based on previous fMRI studies combined with our M/EEG sensitivity maps, we discuss experimental paradigms that are likely to offer high M/EEG sensitivity to cerebellar activity. Taken together, these results show that cerebellar activity should be clearly detectable by current M/EEG systems with an appropriate experimental setup.en_US
dc.language.isoen
dc.publisherWileyen_US
dc.relation.isversionof10.1002/hbm.24951en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceWileyen_US
dc.titleDetectability of cerebellar activity with magnetoencephalography and electroencephalographyen_US
dc.typeArticleen_US
dc.identifier.citationSamuelsson, JG, Sundaram, P, Khan, S, Sereno, MI and Hämäläinen, MS. 2020. "Detectability of cerebellar activity with magnetoencephalography and electroencephalography." Human Brain Mapping, 41 (9).
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technology
dc.relation.journalHuman Brain Mappingen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2022-03-17T15:08:39Z
dspace.orderedauthorsSamuelsson, JG; Sundaram, P; Khan, S; Sereno, MI; Hämäläinen, MSen_US
dspace.date.submission2022-03-17T15:08:42Z
mit.journal.volume41en_US
mit.journal.issue9en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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